# The Physiological and Pathological Mechanisms of LIN2, LIN7, LIN10 and Their Tripartite Complex

## TL;DR

This review explores the roles of LIN2, LIN7, and LIN10 proteins in cell polarity, signaling, and their links to diseases like diabetes and cancer.

## Contribution

The paper systematically summarizes the physiological and pathological roles of LIN2, LIN7, LIN10 and their complex, highlighting their potential as therapeutic targets.

## Key findings

- LIN2, LIN7, and LIN10 are involved in establishing cell polarity and synaptic transmission through specific protein domains.
- The LIN2/7/10 complex is associated with diseases such as type 2 diabetes, cardiovascular disorders, and tumors.
- The review provides a foundation for using these proteins as cancer markers and therapeutic targets.

## Abstract

The LIN family represents a set of conserved proteins that are pivotal in the establishment of cell polarity, the development of synapses and signal transduction processes. Its members, polarity proteins LIN2, LIN7 and LIN10, interact with diverse target proteins via the PDZ domain, SH3‐GK tandem domain and PTB domain. Through these interactions, they are actively engaged in the establishment and modulation of apical‐basal polarity. Moreover, LIN2, LIN7 and LIN10, along with their associated complex LIN2/7/10, participate in the physiological phenomena of synaptic transmission and receptor localisation. In addition, from a pathological perspective, LIN2, LIN7 and LIN10 are intricately linked to the genesis and progression of type 2 diabetes, cardiovascular disorders and a wide spectrum of tumours. This review focuses on the polarity proteins LIN2, LIN7, LIN10 and their complex. It summarises the functions of these molecular domains, systematically arranges their regulatory mechanisms in both physiological and pathological contexts and summarises the current state of research on LIN2, LIN7, LIN10 and their complex. The objective is to furnish a robust theoretical foundation for the prospective utilisation of polarity proteins and their complex as cancer markers and therapeutic targets.