# Weighing options: empiric antibiotic use and stewardship opportunities in critically ill patients with community-acquired pneumonia

**Authors:** Nalea Trujillo, Calvin Diep, David Ha, Ariadna Garcia, Marisa Holubar

PMC · DOI: 10.1017/ash.2025.10082 · 2025-08-07

## TL;DR

This study finds that critically ill patients with pneumonia often get broad antibiotics without clear need, but MRSA treatment is adjusted faster with better testing.

## Contribution

The study highlights empiric antibiotic use patterns and de-escalation opportunities in ICU patients with community-acquired pneumonia.

## Key findings

- Critically ill patients often received empiric anti-MRSA and antipseudomonal antibiotics without clear risk factors.
- De-escalation of anti-MRSA therapy occurred more quickly, possibly due to MRSA PCR assays.

## Abstract

In this retrospective study, critically ill patients with community-acquired pneumonia frequently received empiric anti-methicillin-resistant Staphylococcus aureus (MRSA) and antipseudomonal antibiotics despite having few or no guidelines-endorsed risk factors. De-escalation of anti-MRSA therapy was quicker, likely aided by MRSA polymerase chain reaction assays.

## Linked entities

- **Species:** Staphylococcus aureus (taxon 1280)

## Full-text entities

- **Diseases:** empyema (MESH:D004653), cystic fibrosis (MESH:D003550), neoplastic disease (MESH:D004194), critically ill (MESH:D016638), MRSA (MESH:D013203), neutropenia (MESH:D009503), renal disease (MESH:D007674), related infections (MESH:D007239), COPD (MESH:D029424), cancer (MESH:D009369), extrapulmonary infection (MESH:D000092225), pneumonia (MESH:D011014), CAP (MESH:D003147), lung abscess (MESH:D008169)
- **Chemicals:** methicillin (MESH:D008712)
- **Species:** Homo sapiens (human, species) [taxon 9606], Staphylococcus aureus (species) [taxon 1280], Pseudomonas aeruginosa (species) [taxon 287]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12345047/full.md

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Source: https://tomesphere.com/paper/PMC12345047