# Benign Mesenchymal Tumor of the Vulva: A Case Report and Narrative Review of the Literature

**Authors:** George Mpourazanis, Kostas Tepelenis, Maria Kouvara-Pritsouli, Ioannis Adamopoulos, Konstantina Diamadi, Katerina Ntaflou, Christos Akrivis, Nikolaos Tepelenis, Panagiotis Tsirkas, Ruediger Schulz-Wendtland, Minas Paschopoulos

PMC · DOI: 10.7759/cureus.87807 · 2025-07-13

## TL;DR

A 48-year-old woman had a benign skin growth on her vulva that was surgically removed and did not return after six months.

## Contribution

This case report adds a rare clinical example of a benign mesenchymal tumor in the vulva with detailed histopathological findings.

## Key findings

- The tumor was confirmed as a polypoid proliferation with hypocellular stroma and spindle cells.
- The patient showed no recurrence six months after surgical excision.
- No identifiable risk factors were found for the tumor's rapid growth.

## Abstract

Acrochordons are benign skin neoplasms that originate from mesenchymal and ectodermal tissues. These lesions are commonly found in regions of the skin that experience friction or folding. This report presents a 48-year-old female patient who exhibited a 3 cm acrochordon located on the right labia majora of her vulva. A thorough review of her medical history did not reveal any identifiable risk factors that could account for the onset and rapid growth of the polyp. A wide surgical excision was conducted, and the subsequent histopathological examination confirmed a polypoid proliferation of the stroma, accompanied by a hypocellular stroma composed of spindle cells and loose collagenous stroma. At the six-month follow-up, the patient showed no signs of recurrence.

## Linked entities

- **Diseases:** acrochordon (MONDO:0004026)

## Full-text entities

- **Genes:** ALB (albumin) [NCBI Gene 213] {aka FDAHT, HSA, PRO0883, PRO0903, PRO1341}, SLC17A5 (solute carrier family 17 member 5) [NCBI Gene 26503] {aka AST, ISSD, NSD, SD, SIALIN, SIASD}, GGTLC5P (gamma-glutamyltransferase light chain 5 pseudogene) [NCBI Gene 653590] {aka GGT}, ALPP (alkaline phosphatase, placental) [NCBI Gene 250] {aka ALP, PALP, PLAP, PLAP-1}, CEACAM3 (CEA cell adhesion molecule 3) [NCBI Gene 1084] {aka CD66D, CEA, CGM1, CGM1a, W264, W282}, MUC1 (mucin 1, cell surface associated) [NCBI Gene 4582] {aka ADMCKD, ADMCKD1, ADTKD2, CA 15-3, CD227, Ca15-3}, GGT1 (gamma-glutamyltransferase 1) [NCBI Gene 2678] {aka CD224, D22S672, D22S732, GGT, GGT 1, GGTD}, CRP (C-reactive protein) [NCBI Gene 1401] {aka PTX1}, MUC16 (mucin 16, cell surface associated) [NCBI Gene 94025] {aka CA125}
- **Diseases:** acrochordon (MESH:D058249), pain (MESH:D010146), vulva malignancies (MESH:D014846), Benign Mesenchymal Tumor of (MESH:C535700), FEPs (MESH:D018225), anxiety (MESH:D001007), trauma (MESH:D014947), benign neoplasm (MESH:D009369), polyp (MESH:D011127), infection (MESH:D007239), benign skin neoplasms (MESH:D012878), inflammation (MESH:D007249), vulvar masses (MESH:D014845), adjustment disorders (MESH:D000275), depression (MESH:D003866), papules (MESH:D000169), skin tags (MESH:C566904), soft fibromas (MESH:D005350)
- **Chemicals:** Pap (MESH:D010724), Na+ (MESH:D012964), CRE (-), uric acid (MESH:D014527), creatinine (MESH:D003404), H&amp;E (MESH:D006371), eosin (MESH:D004801), K+ (MESH:D011188), hematoxylin (MESH:D006416), urea (MESH:D014508), alcohol (MESH:D000438), glucose (MESH:D005947)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12344611/full.md

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Source: https://tomesphere.com/paper/PMC12344611