# Extrafollicular Variant of the Common Adenomatoid Odontogenic Tumour: A Rare Case Report

**Authors:** Bhavani N Sangala, Kirti Buva, Saudamini More, Amit Patil, Sandhya Rani Akula, Sanpreet S Sachdev

PMC · DOI: 10.7759/cureus.87846 · 2025-07-13

## TL;DR

This paper reports a rare case of a non-tooth-associated benign tumor in the jaw of a young woman, emphasizing the need for careful diagnosis.

## Contribution

The paper presents a rare extrafollicular variant of AOT not linked to unerupted teeth, offering a case study for diagnostic insights.

## Key findings

- The patient had a well-defined radiolucency with root resorption and tooth displacement in the anterior maxilla.
- Histopathology confirmed the diagnosis of extrafollicular AOT, and conservative surgery led to no recurrence after two years.
- The case underscores the importance of combining clinical, radiological, and histopathological data for accurate diagnosis.

## Abstract

Adenomatoid odontogenic tumour (AOT) is a benign epithelial neoplasm of odontogenic origin, typically seen in young female patients and commonly associated with impacted canines in the anterior maxilla. The extrafollicular variant, which is not associated with unerupted teeth, is relatively rare and may present diagnostic challenges due to its similarity with other odontogenic cysts or tumours. This report presents a case of a 23-year-old female patient with a gradually enlarging swelling in the anterior maxilla. Radiographic imaging revealed a well-defined radiolucency with root resorption and displacement of adjacent teeth. Histopathological examination confirmed the diagnosis of extrafollicular AOT. The lesion was managed successfully with conservative surgical excision, and no recurrence was noted during a two-year follow-up. This case highlights the importance of integrating clinical, radiological, and histopathological findings for accurate diagnosis and appropriate management of this rare AOT variant.

## Full-text entities

- **Genes:** PCNA (proliferating cell nuclear antigen) [NCBI Gene 477166], TP53 (tumor protein p53) [NCBI Gene 403869] {aka P53}
- **Diseases:** resorption (MESH:D014091), Root resorption (MESH:D012391), anterior maxillary radiolucencies (MESH:D008439), inflammation (MESH:D007249), fold (MESH:D057165), inflammatory odontogenic lesions (MESH:D009808), periapical cysts (MESH:D011842), periapical or residual cyst (MESH:D018365), granulomas (MESH:D006099), cysts (MESH:D003560), ameloblastoma (MESH:D000564), calcifying odontogenic cyst (MESH:D018333), unerupted (MESH:D014097), calcifying epithelial odontogenic tumour (MESH:C537961), calcification (MESH:D002114), benign (MESH:D009369), AOT (MESH:C538229), Swelling (MESH:D004487), periapical pathologies (MESH:D010483), giant cell granulomas (MESH:D006101), odontogenic cysts (MESH:D009807), epithelial adamantinoma (MESH:D009375)
- **Chemicals:** Eosin (MESH:D004801), hematoxylin (MESH:D006416), H &amp; E (MESH:D006371), Hematoxylin and Eosin (-)
- **Species:** Homo sapiens (human, species) [taxon 9606], Canis lupus familiaris (dog, subspecies) [taxon 9615]

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12344608/full.md

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Source: https://tomesphere.com/paper/PMC12344608