# Vaginal bacteria and cervical cancer: a bibliometric analysis of trends and themes

**Authors:** Xiaoxia Liu, Yinghui Zhao, Xianhua Meng, Zheng Gao, Xiaohong Wang, Fengyong Yang

PMC · DOI: 10.3389/fmicb.2025.1615944 · 2025-07-30

## TL;DR

This study uses bibliometric analysis to track global research trends on how vaginal bacteria relate to cervical cancer, identifying key themes and contributors.

## Contribution

The study provides a comprehensive bibliometric analysis of vaginal bacteria and cervical cancer research, revealing emerging trends and collaboration patterns.

## Key findings

- Global research on vaginal bacteria and cervical cancer has grown at an annual rate of 8.41%.
- China and the USA are leading contributors, with 'bacterial vaginosis' and 'lactobacillus' as key research themes.
- Emerging trends include the use of '16 s rRNA gene sequencing' and focus on 'intraepithelial neoplasia'.

## Abstract

Cervical cancer remains a significant global health challenge, with increasing evidence suggesting the crucial role of vaginal bacteria in its development and progression. This study aims to analyze the global research landscape and trends in vaginal bacteria and cervical cancer research through bibliometric analysis.

Literature data were retrieved from the Web of Science Core Collection (WOSCC) database. Bibliometric analysis was performed using VOSviewer, CiteSpace, and R-bibliometrix to evaluate publication patterns, research collaboration networks, and emerging trends.

A total of 372 publications were identified, showing an annual growth rate of 8.41%. China and USA emerged as leading contributors, with the Imperial College London and University of Arizona being the most productive institutions. Herbst-Kralovetz MM and Laniewski P were identified as the most influential authors, while BMC Infectious Diseases and Frontiers in Cellular and Infection Microbiology were the primary publication venues. Keyword co-occurrence analysis identified “bacterial vaginosis,” “women,” and “inflammation” as the most frequent terms, while burst detection revealed emerging research trends in “lactobacillus,” “intraepithelial neoplasia,” and “16 s rRNA gene sequencing.”

This bibliometric analysis provides comprehensive insights into the evolution and current status of vaginal bacteria research in cervical cancer, highlighting key research themes and collaborative patterns. These findings offer valuable guidance for future research directions and potential clinical applications in cervical cancer prevention and treatment strategies.

## Linked entities

- **Diseases:** cervical cancer (MONDO:0002974), bacterial vaginosis (MONDO:0005316)

## Full-text entities

- **Diseases:** invasive cancer (MESH:D009362), Cervical cancer (MESH:D002583), Infection (MESH:D007239), cervical carcinogenesis (MESH:D063646), cancer (MESH:D009369), precancerous lesions (MESH:D011230), sexually transmitted infections (MESH:D012749), vaginitides (MESH:D014627), Cervical Disease (MESH:D002575), bacterial vaginosis (MESH:D016585), invasive (MESH:D009361), trichomonas vaginalis (MESH:D014245), HPV infection (MESH:D030361), Infectious Diseases (MESH:D003141), candida (MESH:D002177), CIN (MESH:D002578), Inflammatory (MESH:D007249)
- **Chemicals:** cadaverine (MESH:D002103), putrescine (MESH:D011700), lactobacill (-), polyamines (MESH:D011073), succinate (MESH:D019802), short-chain fatty acids (MESH:D005232), D-lactic acid (MESH:D019344), acetate (MESH:D000085)
- **Species:** Homo sapiens (human, species) [taxon 9606], Human papillomavirus (species) [taxon 10566], Fannyhessea vaginae (species) [taxon 82135], Ureaplasma urealyticum (species) [taxon 2130], Lactobacillus jensenii (species) [taxon 109790], Bacteria Latreille et al. 1825 (Bacteria stick insect, genus) [taxon 629395], Gardnerella vaginalis (species) [taxon 2702], Prevotella bivia (species) [taxon 28125], Lactobacillus crispatus (species) [taxon 47770]

## Figures

8 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12343664/full.md

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Source: https://tomesphere.com/paper/PMC12343664