# Editorial: Pathogenic potassium channel variants in neurological disorders: from functional analysis to personalized pharmacological approaches

**Authors:** Ilenio Servettini, Luca Guglielmi, Luigi Sforna, Luigi Catacuzzeno

PMC · DOI: 10.3389/fncel.2025.1614320 · 2025-07-30

## Full-text entities

- **Genes:** kcnb1.S (potassium channel, voltage gated Shab related subfamily B, member 1 S homeolog) [NCBI Gene 378535] {aka XShab9, drk1, kcnb1, kcnb1-A, kcnb1.L, kv2.1}, ACHE (acetylcholinesterase (Yt blood group)) [NCBI Gene 43] {aka ACEE, ARACHE, N-ACHE, YT}, KCNQ2 (potassium voltage-gated channel subfamily Q member 2) [NCBI Gene 3785] {aka BFNC, DEE7, EBN, EBN1, ENB1, HNSPC}, KCNC1 (potassium voltage-gated channel subfamily C member 1) [NCBI Gene 3746] {aka EPM7, KV3.1, KV4, NGK2}, KCNT1 (potassium sodium-activated channel subfamily T member 1) [NCBI Gene 57582] {aka DEE14, EIEE14, ENFL5, KCa4.1, KNa1.1, SLACK}, KCNC3 (potassium voltage-gated channel subfamily C member 3) [NCBI Gene 3748] {aka KSHIIID, KV3.3, SCA13}, KCNQ3 (potassium voltage-gated channel subfamily Q member 3) [NCBI Gene 3786] {aka BFNC2, EBN2, KV7.3}
- **Diseases:** PTSD (MESH:D013313), epilepsies (MESH:D004827), developmental encephalopathy (MESH:C567924), behavioral disorders (MESH:D001523), autism (MESH:D001321), neurological disease (MESH:D020271), intellectual disability (MESH:D008607), ataxia (MESH:D001259), autism spectrum disorders (MESH:D000067877), seizure (MESH:D012640), neurocognitive delay (MESH:D019965), K+ channel disfunction (MESH:D014813), spinocerebellar ataxia type 13 (MESH:C537195), developmental delay (MESH:D002658), neurological disorders (MESH:D009461)
- **Chemicals:** fluoxetine (MESH:D005473), K+ (MESH:D011188), Gabapentin (MESH:D000077206), donepezil (MESH:D000077265)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606], Xenopus laevis (African clawed frog, species) [taxon 8355]
- **Mutations:** p.E675K, p.S114R, S937G, P385L, P385T
- **Cell lines:** CHO — Cricetulus griseus (Chinese hamster), Spontaneously immortalized cell line (CVCL_0213)

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Source: https://tomesphere.com/paper/PMC12343496