# Systemic Sarcoidosis Mimicking Metastatic Invasive Ductal Carcinoma of the Breast

**Authors:** Sai R Vulasala, Christopher D Louviere, Farah Navarro, Grit A Adler, Dheeraj R Gopireddy, Parlyn Hatch, Renato Abu Hana

PMC · DOI: 10.7759/cureus.87860 · 2025-07-13

## TL;DR

A case is reported where systemic sarcoidosis was mistaken for metastatic breast cancer, highlighting the importance of accurate diagnosis.

## Contribution

The paper presents a clinical case emphasizing the diagnostic challenges between sarcoidosis and metastatic cancer.

## Key findings

- Systemic sarcoidosis can mimic metastatic invasive ductal carcinoma of the breast.
- Tumor markers and histopathology are essential for distinguishing sarcoidosis from metastatic disease.

## Abstract

Sarcoidosis is a granulomatous inflammatory disorder of uncertain etiology that can closely mimic metastatic malignancies, particularly when it presents with multi-organ involvement. In patients with a confirmed diagnosis of cancer, to avoid misdiagnosis and subsequent inappropriate treatment, distinguishing between sarcoidosis and metastatic disease is essential. Histologic confirmation through tissue sampling and correlation with tumor markers are critical tools in this process. We report a case of a 36-year-old female with invasive ductal carcinoma of the breast who presented with suspicious findings that indicated metastatic disease involving her lungs, liver, and bones. However, tumor marker levels and histopathology revealed systemic sarcoidosis, not metastatic spread.

## Linked entities

- **Diseases:** sarcoidosis (MONDO:0008399), invasive ductal carcinoma (MONDO:0004953), metastatic disease (MONDO:0024883)

## Full-text entities

- **Genes:** ERBB2 (erb-b2 receptor tyrosine kinase 2) [NCBI Gene 2064] {aka CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19}, ESR1 (estrogen receptor 1) [NCBI Gene 2099] {aka ER, ESR, ESRA, ESTRR, Era, NR3A1}, MUC1 (mucin 1, cell surface associated) [NCBI Gene 4582] {aka ADMCKD, ADMCKD1, ADTKD2, CA 15-3, CD227, Ca15-3}, ADA2 (adenosine deaminase 2) [NCBI Gene 51816] {aka ADGF, CECR1, IDGFL, PAN, SNEDS, VAIHS}, ALB (albumin) [NCBI Gene 213] {aka FDAHT, HSA, PRO0883, PRO0903, PRO1341}
- **Diseases:** weight loss (MESH:D015431), granuloma (MESH:D006099), disease (MESH:D004194), iliac lesion (MESH:D017543), breast (MESH:D061325), Ductal Carcinoma of the (MESH:D044584), Breast cancer (MESH:D001943), granulomatous infectious (MESH:D003141), bone disease (MESH:D001847), granulomatous inflammation (MESH:D007249), oncologic (MESH:D000072716), Invasive Ductal Carcinoma of the Breast (MESH:D018270), stress fractures (MESH:D015775), lymphadenopathy (MESH:D008206), metastases (MESH:D009362), cancer (MESH:D009369), mediastinal lymphadenopathy (MESH:D008477), lymph node metastases (MESH:D008207), metastatic disease (MESH:D000092182), Sarcoidosis (MESH:D012507), lymphoma (MESH:D008223), osteomyelitis (MESH:D010019), liver lesions (MESH:D008107), multiple myeloma (MESH:D009101), Granulomatous disorders (MESH:D006105), axial tuberculosis (MESH:D014376), joint pain (MESH:D018771), fatigue (MESH:D005221), bone pain (MESH:D010146), autoimmune attacks (MESH:D001327)
- **Chemicals:** 18F-fluorodeoxyglucose (MESH:D019788), H&amp;E (MESH:D006371), docetaxel (MESH:D000077143), trastuzumab (MESH:D000068878), pertuzumab (MESH:C485206), gadolinium (MESH:D005682), Grocott methenamine silver (-), carboplatin (MESH:D016190), GMS (MESH:C009032)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12343365/full.md

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Source: https://tomesphere.com/paper/PMC12343365