# Investigation of the temporal distribution of anti-VEGF drugs in the retina and the correlation with the distribution of FcR isoforms

**Authors:** Jicai He, Yanping Jiang, Rongqin Yang, Ziwen Lu, Zhihuan Li, Zhigang Tu

PMC · DOI: 10.1016/j.gendis.2025.101698 · 2025-05-28

## Full-text entities

- **Genes:** Fcgr2b (Fc gamma receptor 2B) [NCBI Gene 289211] {aka CD32, FCRII, FcgammaRIIB2, Fcgr2}, Fcgr1a (Fc gamma receptor 1A) [NCBI Gene 295279] {aka FcgammaRI, Fcgr1, Fcgr1b}, Vegfa (vascular endothelial growth factor A) [NCBI Gene 83785] {aka VEGF-A, VEGF111, VEGF164, VPF, Vegf}, Fcgrt (Fc gamma receptor and transporter) [NCBI Gene 29558] {aka FcRn}, VEGFA (vascular endothelial growth factor A) [NCBI Gene 7422] {aka L-VEGF, MVCD1, VEGF, VPF}, Fcgr2a (Fc gamma receptor 2A) [NCBI Gene 116591] {aka Fcgr3, Fcgr3a, fc-gamma RIII, fcRIII}
- **Diseases:** inflammation (MESH:D007249), retinal vein occlusion (MESH:D012170), vision loss (MESH:D014786), retinal edema (MESH:D010211), type 1 nAMD (MESH:C566411), diabetic macular edema (MESH:D008269), AMD (MESH:D008268), Cancer (MESH:D009369), choroidal neovascularization (MESH:D020256)
- **Chemicals:** Bevacizumab (MESH:D000068258), Brolucizumab (MESH:C000622091), Ranibizumab (MESH:D000069579)
- **Species:** Rattus norvegicus (brown rat, species) [taxon 10116], Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12343353/full.md

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Source: https://tomesphere.com/paper/PMC12343353