# Adult-Onset Still’s Disease in a 49-Year-Old Female in the UAE: A Case Report and Literature Review

## TL;DR

A rare case of Adult-Onset Still’s Disease in a 49-year-old woman in the UAE is reported, highlighting diagnostic challenges and treatment with corticosteroids and tocilizumab.

## Contribution

This is the first documented case of AOSD in the UAE, emphasizing the role of ferritin and IL-6 inhibition in diagnosis and treatment.

## Key findings

- The patient met Yamaguchi criteria for AOSD with high ferritin levels and clinical symptoms.
- Treatment with corticosteroids and tocilizumab led to significant clinical improvement.
- The case highlights the importance of considering AOSD in differential diagnoses in the UAE.

## Abstract

Adult-onset Still’s disease (AOSD) is a rare autoinflammatory disorder characterized by high spiking fevers, salmon-colored rash, arthritis, and hyperferritinemia. It often mimics infections or autoimmune conditions, leading to diagnostic delays. We report a case of a 49-year-old female who presented with fever, fatigue, arthralgia, evanescent rash, and elevated inflammatory markers. Extensive infectious and autoimmune workups were negative. Her serum ferritin exceeded 16,000 ng/mL. She fulfilled the Yamaguchi criteria for AOSD, and treatment with corticosteroids followed by tocilizumab resulted in marked clinical improvement. This is, to our knowledge, the first documented case of AOSD from the UAE. It underscores the importance of ferritin in diagnosis and disease monitoring and highlights the efficacy of interleukin (IL)-6 inhibition in management.