# Co-Infection of Pulmonary Aspergillosis and Cryptococcal Meningitis in an HIV-Positive Patient: A Case Report

**Authors:** Marjan Hemmatian, Sadegh Khodavaisy, Hossein Kazemizadeh, Behnaz Jahanbin, Reza Ershadi, Maryam Moradi, Mohammadreza Salehi, Jianping Xu, Megan Hitchcock, Kazem Ahmadikia, Ali Ahmadi, Seyed Ali Dehghan Manshadi

PMC · DOI: 10.1155/crdi/5630156 · Case Reports in Infectious Diseases · 2025-08-05

## TL;DR

This case report describes an HIV patient with a very low immune cell count who developed two serious fungal infections at the same time.

## Contribution

The novelty lies in documenting a rare co-infection of pulmonary aspergillosis and cryptococcal meningitis in a late-diagnosed HIV patient.

## Key findings

- The patient had both pulmonary aspergillosis and cryptococcal meningitis.
- The infections occurred in an HIV-positive individual with a CD4 count below 100.
- This case highlights the risk of multiple opportunistic fungal infections in late-diagnosed HIV patients.

## Abstract

Opportunistic fungal infections (OFIs) are common among human immunodeficiency virus (HIV) –positive patients, especially in those with delayed diagnosis and treatment. Patients with severe HIV/AIDS with clusters of differentiation 4 (CD4) counts less than 100 are significantly prone to develop multiple OFIs. In the current study, we present a case of co-infection of pulmonary aspergillosis and cryptococcal meningitis in a late-diagnosed HIV patient with a low CD4 count.

## Linked entities

- **Diseases:** cryptococcal meningitis (MONDO:0005723), AIDS (MONDO:0012268)

## Full-text entities

- **Genes:** CD4 (CD4 molecule) [NCBI Gene 920] {aka CD4mut, IMD79, Leu-3, OKT4D, T4}
- **Diseases:** OFIs (MESH:D009181), Pulmonary Aspergillosis (MESH:D055732), Co-Infection (MESH:D060085), HIV/AIDS (MESH:D016263), Cryptococcal Meningitis (MESH:D016919)
- **Species:** Human immunodeficiency virus (species) [taxon 12721], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12343162/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12343162/full.md

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Source: https://tomesphere.com/paper/PMC12343162