# A case report of hereditary spherocytosis complicated by massive splenomegaly and cholelithiasis

## TL;DR

A 53-year-old man with hereditary spherocytosis had severe spleen enlargement and gallstones, which improved after combined surgery.

## Contribution

This case report highlights the effectiveness of combined splenectomy and cholecystectomy in managing HS complications.

## Key findings

- Combined splenectomy and cholecystectomy alleviated hemolytic jaundice, anemia, and gallstone symptoms.
- Personalized comprehensive treatment improves prognosis in hereditary spherocytosis patients with multiple complications.

## Abstract

Here, we report the case of a 53-year-old male patient with hereditary spherocytosis (HS) and a 10-year course of disease, presenting with fatigue, jaundice, abdominal discomfort, massive splenomegaly (spleen size: 35 × 20 × 10 cm, weight: 10 kg), and cholelithiasis. The patient had a positive family history, with his father and daughter exhibiting similar symptoms. Combined splenectomy and cholecystectomy significantly alleviated hemolytic jaundice, anemia, and gallstone-related symptoms. HS is an autosomal dominant disorder affecting erythrocyte membranes. Splenectomy effectively improves hemolytic anemia, while concurrent cholecystectomy is necessary to comprehensively manage cholelithiasis. This case highlights the clinical value of combined surgery for HS-related complications, emphasizing that personalized comprehensive treatment optimizes prognosis.