# Response to “Antiviral RNA silencing in mammals: the importance of selecting the appropriate experimental model”

## TL;DR

The authors respond to a commentary on their work about antiviral RNA silencing in mammals, clarifying their experimental model and findings.

## Contribution

The paper provides clarifications and additional information to address concerns raised about their experimental model and RNA interference in mammals.

## Key findings

- The authors agree with some points raised in the commentary about virus–host system complexity.
- They clarify aspects of their animal model system and mammalian RNA interference.
- The response aims to improve understanding of their experimental approach.

## Abstract

In their commentary Antiviral RNA silencing in mammals: the importance of selecting the appropriate experimental model, Xing Liu and Yang Li critically review our recent work by Kulmann et al. published in Nucleic Acids Research. While we agree with authors on a number of their points, especially those concerning complexity of virus–host systems, we would like to add some missing information and clarify several important aspects of our animal model system and mammalian canonical RNA interference in general.