# An 80-year-old female with multiple mononeuropathy: neuroleukemiosis a rare complication of chronic lymphocytic leukaemia

**Authors:** Caroline Morgan, Venkataramanan Srinivasan, Ute Pohl, Benjamin R Wakerley

PMC · DOI: 10.1093/omcr/omaf131 · Oxford Medical Case Reports · 2025-08-11

## TL;DR

An 80-year-old woman with chronic lymphocytic leukemia developed a rare nerve condition called neuroleukemiosis, confirmed through biopsy.

## Contribution

This case highlights neuroleukemiosis as a rare complication of chronic lymphocytic leukemia.

## Key findings

- The patient presented with painful footdrop and multiple mononeuropathy.
- A nerve biopsy confirmed small lymphocyte infiltration in the epineurium and perineurium.
- The diagnosis of neuroleukemiosis was established based on clinical and pathological findings.

## Abstract

We report the case of an 80-year-old lady with chronic lymphocytic leukaemia who presented with painful footdrop. Nerve conduction studies and electromyography confirmed the presence of multiple mononeuropathy. Left superficial radial nerve biopsy revealed small lymphocytes infiltrating the epineurium and perineurium and confirmed a diagnosis of neuroleukemiosis.

## Full-text entities

- **Genes:** CD5 (CD5 molecule) [NCBI Gene 921] {aka LEU1, T1}, FCER2 (Fc epsilon receptor II) [NCBI Gene 2208] {aka BLAST-2, CD23, CD23A, CLEC4J, FCE2, FCErII}, KRT20 (keratin 20) [NCBI Gene 54474] {aka CD20, CK-20, CK20, K20, KRT21}, MPO (myeloperoxidase) [NCBI Gene 4353]
- **Diseases:** Vasculitis (MESH:D014657), acute leukaemia (MESH:D054218), pain (MESH:D010146), leukaemia (MESH:D015458), mass (MESH:C536030), organomegaly (MESH:D016878), peripheral nerve damage (MESH:D010523), foot drop (MESH:D020427), CLL (MESH:D015461), CTS (MESH:D002349), axonal lesion (MESH:D004194), neurological deficits (MESH:D009461), adenopathy (MESH:D000072281), multiple (MESH:D009104), axonal neuropathy (MESH:D020269), nerve infiltration (MESH:D010524), mononeuropathy (MESH:D020422), Blood borne virus (MESH:D000086982), lymphoproliferative disorder (MESH:D008232), leukemic (MESH:D007938), median nerve dysfunction (MESH:D020423), demyelinating neuropathy (MESH:D003711), ulnar nerve dysfunction (MESH:D020424), lymphadenopathy (MESH:D008206)
- **Chemicals:** B12 (MESH:C034730), FDG (MESH:D019788), folate (MESH:D005492), HE (MESH:D006371)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12342899/full.md

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Source: https://tomesphere.com/paper/PMC12342899