# Effectiveness Of The Core Activation And Rehabilitation Exercises For Knee Osteoarthritis - Program (CARE -KOA ©) Among Patients Diagnosed With Knee Osteoarthritis

**Authors:** Dias Tina Thomas, Charu Eapen, Atmananda S Hegde, Ajit R. Mahale, Prajwal Prabhudev Mane, Saurabh Mehta, Peeyoosha Gurudut, Varun Naik

PMC · DOI: 10.12688/f1000research.163321.1 · F1000Research · 2025-05-15

## TL;DR

A new 4-week exercise program called CARE-KOA© reduced pain and improved function in patients with knee osteoarthritis.

## Contribution

The study introduces and evaluates the CARE-KOA© program, which integrates core activation and rehabilitation for knee osteoarthritis.

## Key findings

- The program significantly reduced pain and improved patient-reported outcomes.
- Most physical function tests showed significant improvement after the intervention.
- Knee muscle strength in some groups did not show significant changes.

## Abstract

Knee osteoarthritis (KOA) is a prevalent condition. Recent research on people with KOA has addressed kinetic chain and core muscle contribution in disease progression.

This study aims to assess the efficacy of including the CARE -KOA© regimen and evaluate its effect on pain, patient-reported functional outcomes, physical function tests, knee strength, and core endurance.

15 patients above 45 were recruited and underwent a 4-week CARE -KOA© program with 12 supervised sessions over four weeks. Pre- and Post-exercise assessment included evaluating the primary outcome pain using the VAS scale and the patient-reported outcome using the KOOS scale. The secondary outcomes, knee muscle strength, core endurance, and the physical function tests, i.e., the stair climb test, the sit-to-stand test, the 40m fast-paced walking test, and the timed up-and-go test, were also evaluated. The data collected in the study was analyzed using the statistical software
JAMOVI.
p < 0.05 was significant.

Notably, all the parameters examined exhibited a statistically significant difference between their pre-intervention and post-intervention values, except the knee muscle strength in the flexors of the affected knee and extensors of the unaffected knee.

Patients who completed a 4-week supervised CARE -KOA© program alongside routine rehabilitation experienced reduced pain and improved outcomes. This approach aims to address biomechanical issues and positively impacts pain mechanisms.

CTRI/2023/07/05480 on 05/07/2024
https://ctri.nic.in/Clinicaltrials/regtrial.php?modid=1&compid=19&EncHid=69416.70327

Copy right registration: L – 158197/2024

## Full-text entities

- **Diseases:** pain (MESH:D010146), KOA (MESH:D020370)
- **Chemicals:** CARE (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12340487/full.md

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Source: https://tomesphere.com/paper/PMC12340487