# Ketone body, as an emerging modulator of metabolic reprogramming and epigenetics in breast cancer

## TL;DR

This paper reviews how ketone bodies affect breast cancer cell metabolism and epigenetics, exploring their potential as a treatment strategy.

## Contribution

The paper provides a comprehensive review of the role of ketone bodies in metabolic reprogramming and epigenetic changes in breast cancer.

## Key findings

- Breast cancer cells rely on glucose metabolism, which influences their invasive potential.
- Ketone bodies may alter cancer cell metabolism and epigenetic patterns, with conflicting results on their impact on invasiveness.
- Ketogenic diets are being explored as a potential strategy to combat cancer by altering energy sources.

## Abstract

The metabolic profile of cancer cells, notably their reliance on glucose as a primary energy source for proliferation, sets them apart from normal cells. This metabolic dependency may significantly affect their invasive potential when an adequate glucose supply is available. Moreover, emerging evidence underscores the critical role of metabolism in determining the epigenetic landscape of cells. To limit the glucose supply and alter cancer cell metabolism, researchers have investigated ketogenic diets as an alternative energy source for cancer cells and providing a promising strategy to combat cancers. However, controversial findings in the literature suggest a direct relationship between the use of ketone bodies in cancer cells and the augmentation of invasiveness. Additionally, studies indicate that using ketone bodies as an energy source can influence the epigenetic patterns of tumor cells. Breast cancer cells show a unique metabolism by which the cancer cells adapt to various conditions. This paper aims to review the metabolic characteristics of breast tumors, focusing on the ketone body metabolism in this cancer and the complex interplay between ketone bodies and the epigenetic changes in this cancer.