# Editorial: Lymphatic system: organ specific functions in health and disease, volume II

**Authors:** Zoltán Jakus, Young-Kwon Hong, Tsutomu Kume

PMC · DOI: 10.3389/fcell.2025.1659266 · Frontiers in Cell and Developmental Biology · 2025-07-29

## Full-text entities

- **Genes:** VEGFC (vascular endothelial growth factor C) [NCBI Gene 7424] {aka Flt4-L, LMPH1D, LMPHM4, VRP}, KDR (kinase insert domain receptor) [NCBI Gene 3791] {aka CD309, FLK1, VEGFR, VEGFR2}, Kras (Kras proto-oncogene, GTPase) [NCBI Gene 16653] {aka K-Ras, K-Ras 2, K-ras, Ki-ras, Kras-2, Kras2}, RSPO3 (R-spondin 3) [NCBI Gene 84870] {aka CRISTIN1, PWTSR, THSD2}, RELN (reelin) [NCBI Gene 5649] {aka ETL7, LIS2, PRO1598, RL}, CD4 (CD4 molecule) [NCBI Gene 920] {aka CD4mut, IMD79, Leu-3, OKT4D, T4}, F2 (coagulation factor II, thrombin) [NCBI Gene 2147] {aka PT, RPRGL2, THPH1}, APLN (apelin) [NCBI Gene 8862] {aka APEL, XNPEP2}, FLT4 (fms related receptor tyrosine kinase 4) [NCBI Gene 2324] {aka CHTD7, FLT-4, FLT41, LMPH1A, LMPHM1, PCL}
- **Diseases:** cardiac and intestinal disease (MESH:D007410), CNS diseases (MESH:D002493), neurological diseases (MESH:D020271), hypertrophy (MESH:D006984), injury (MESH:D014947), fibrosis (MESH:D005355), developmental disorders (MESH:D002658), Secondary lymphedema (MESH:D008209), Parkinson's disease (MESH:D010300), filariasis (MESH:D005368), lymphatic disorders (MESH:D008206), COPD (MESH:D029424), multiple sclerosis (MESH:D009103), inflammation (MESH:D007249), lymphangiectasia (MESH:D008201), neurotoxic (MESH:D020258), chronic (MESH:D002908), Alzheimer's disease (MESH:D000544), CLAs (MESH:D044148), genital oedema (MESH:C536897)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Homo sapiens (human, species) [taxon 9606]
- **Mutations:** p.G12D

## Full text

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## References

2 references — full list in the complete paper: https://tomesphere.com/paper/PMC12340404/full.md

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Source: https://tomesphere.com/paper/PMC12340404