# Gut microbiome dysregulation in noninfectious uveitis

## TL;DR

This paper explores how gut microbiome imbalances may contribute to noninfectious uveitis and suggests potential therapies to reshape gut microbes for treatment.

## Contribution

The paper summarizes current evidence and mechanisms linking gut microbiome dysregulation to noninfectious uveitis and proposes novel therapeutic strategies.

## Key findings

- Gut microbiome dysbiosis may influence noninfectious uveitis through mechanisms like translocation and molecular mimicry.
- Therapeutic approaches like probiotics and fecal microbial transplantation may help reshape gut microbiota to treat NIU.
- Understanding gut-eye axis regulation could provide a foundation for new treatment strategies.

## Abstract

Noninfectious uveitis (NIU) is a vision-threatening autoimmune disease of the eye, but its pathogenesis is still not fully understood. Recently, accumulating evidence suggests that gut microbiome dysbiosis may affect the development and progression of NIU through potential mechanisms, including translocation, molecular mimicry, and bystander activation. Understanding the mechanisms of gut microbiome-host interactions, especially the gut-eye axis regulation, can offer a theoretical foundation for developing novel therapeutic strategies. We summarized current evidence on the dysregulation of gut microbiome and metabolites in NIU, and explored potential mechanisms involved. Furthermore, possible therapeutic measures are discussed, including probiotics, prebiotics, dietary modifications, antibiotic interventions, as well as fecal microbial transplantation, aiming to exert beneficial effects on NIU progression by reshaping the gut microbial composition.