# Case Report: A female patient with gastrointestinal perforation, acute diffuse peritonitis, and Crohn's disease needs homeostasis management

**Authors:** Dai-Liang Fei, Ze Yu, Wan-Neng Yan, Jin-Liang Dong

PMC · DOI: 10.3389/fmed.2025.1557305 · Frontiers in Medicine · 2025-07-29

## TL;DR

A 47-year-old woman with Crohn's disease experienced gastrointestinal perforation and peritonitis, requiring multiple surgeries and intensive care before recovery.

## Contribution

This case report highlights the challenges of managing intestinal perforation in Crohn's disease patients and emphasizes the need for timely surgical and postoperative care.

## Key findings

- The patient required two surgeries due to complications from gastrointestinal perforation and anastomotic leakage.
- Intensive care and nutritional support were crucial for recovery from short bowel syndrome.
- The case emphasizes the importance of prompt surgical intervention and comprehensive postoperative management in Crohn's disease patients.

## Abstract

A 47-year-old married woman presented with abdominal discomfort, distension, and nausea following a two-day episode of constipation accompanied by reduced urine output. Upon her admission, a physical assessment indicated tachycardia and abdominal sensitivity, while imaging examinations corroborated gastrointestinal perforation along with signs of acute diffuse peritonitis. The patient had a prior history of Crohn's disease and had been off medication for over a year. The initial surgical intervention entailed bowel resection and adhesiolysis; however, postoperative complications arose, prompting a second operation due to suspected anastomotic leakage and a severe infection. In spite of these challenges, the patient received intensive care, nutritional support, and treatment for short bowel syndrome. Over span of a month, her health significantly improved, and she was ultimately discharged with ongoing management for her Crohn's disease. This case underscores the intricacies involved in addressing intestinal perforations in patients with pre-existing Crohn's disease and highlights the imperative for prompt surgical action and comprehensive postoperative care.

## Linked entities

- **Diseases:** Crohn's disease (MONDO:0005011), short bowel syndrome (MONDO:0015183)

## Full-text entities

- **Diseases:** abdominal discomfort (MESH:D000007), short bowel syndrome (MESH:D012778), gastrointestinal perforation (MESH:D005767), tachycardia (MESH:D013610), peritonitis (MESH:D010538), nausea (MESH:D009325), constipation (MESH:D003248), perforations (MESH:D057112), anastomotic leakage (MESH:D057868), infection (MESH:D007239), Crohn's disease (MESH:D003424)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12339427/full.md

## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC12339427/full.md

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Source: https://tomesphere.com/paper/PMC12339427