# Moderate Beer Consumption Ameliorated Aging‐Related Metabolic Disorders Induced by D‐Galactose in Mice via Modulating Gut Microbiota Dysbiosis

## TL;DR

Moderate beer consumption in mice reduced aging-related health issues by improving gut bacteria balance.

## Contribution

This study is the first to compare the anti-aging effects of three beer types on metabolic disorders via gut microbiota modulation.

## Key findings

- IPA and Stout improved liver and kidney health in mice more than Original beer.
- Stout showed the strongest effect in reducing oxidative damage caused by aging.
- All beers increased beneficial gut bacteria and reduced harmful ones.

## Abstract

The process of aging is a multifaceted physiological phenomenon that entails the gradual deterioration of physical health. In recent years, fermented foods have garnered significant attention for their potential anti‐aging benefits; however, the effects of moderate consumption of beer on aging‐related metabolic disorders remain unexplored. Original beer, India Pale Ale (IPA), and Stout are widely consumed alcoholic beverages on a global scale. The objective of this study is to investigate and compare the effect of moderate consumption of these beers on aging‐related metabolic disorders in mice induced by D‐galactose (D‐gal), encompassing inflammation, organ impairment, oxidative stress, and dyslipidemia. Furthermore, potential mechanisms were elucidated through analysis of gut microbiota. Compared to the Original beer, oral administration of IPA and Stout effectively improved liver and kidney health in mice. All beers mitigated serum oxidative damage induced by D‐gal, with Stout exhibiting a more significant effect. Additionally, the Original beer was more effective at restoring intestinal microbiota diversity. Moreover, the tested beers elicited modifications in the composition of intestinal microbiota, including a decline in Firmicutes abundance and an elevation in Bacteroidota levels, accompanied by a decrease in harmful bacteria like Deferribacterota and an increase in beneficial bacteria like Lactobacillus and Roseburia. The research findings suggest that moderate consumption of Original beer, IPA, and Stout possesses the potential to mitigate D‐gal‐induced metabolic disorders through modulation of gut microbiota dysbiosis. Consequently, these results provide valuable insights into the favorable impacts associated with moderate beer consumption on human aging and health.

The present study conducted a comparative analysis of the effects of moderate consumption of three prevalent beer types—Original beer, India Pale Ale (IPA), and Stout—on D‐galactose‐induced aging in mice. The findings demonstrate that the tested beers exhibit potential in mitigating metabolic disorders encompassing oxidative stress, inflammation levels, liver function, and blood lipid profiles. Furthermore, investigation into gut microbiota reveals that these beers enhance microbial diversity while promoting beneficial bacteria and suppressing harmful bacteria associated with aging, thereby exerting anti‐aging properties.