# Fufang Taizishen Granules Attenuate Chemotherapy‐Induced Intestinal Mucositis by Modulating Gut Microbiota and Amino Acid Metabolism

## TL;DR

Fufang Taizishen granules reduce chemotherapy-induced intestinal damage in mice by improving gut health and metabolism.

## Contribution

FFTZS is shown to alleviate intestinal mucositis through gut microbiota modulation and amino acid metabolism restoration.

## Key findings

- FFTZS improved clinical symptoms like food intake and diarrhea in mice with intestinal mucositis.
- FFTZS increased expression of proteins that maintain gut barrier integrity, such as Claudin-1 and ZO-1.
- FFTZS corrected chemotherapy-induced amino acid metabolic disturbances and modulated gut microbiota.

## Abstract

Chemotherapy‐induced intestinal mucositis is a severe adverse effect affecting cancer patients, and there are currently no effective strategies for its prevention. Fufang Taizishen granules (FFTZS), a traditional Chinese medicine (TCM) known for its anti‐inflammatory, anti‐fatigue, and immunostimulatory properties, have shown therapeutic potential. However, the effects of FFTZS on chemotherapy‐induced intestinal mucositis and its underlying mechanisms remain unclear. A mouse model of intestinal mucositis was induced using 5‐FU and irinotecan to assess the protective effects of FFTZS. The study found that FFTZS enhanced food intake, reduced diarrhea index, and improved histopathological damage in colonic tissues. FFTZS also reduced inflammatory cell infiltration and inhibited apoptosis. Moreover, FFTZS treatment increased the expression of Claudin‐1 and ZO‐1 proteins. Microbial analysis revealed an enrichment of beneficial bacteria and a reduction of opportunistic pathogens, whereas metabolomic analysis showed that FFTZS corrected amino acid metabolic disturbances induced by chemotherapy. These findings suggest that FFTZS mitigates chemotherapy‐induced intestinal mucositis by preserving mucosal integrity, modulating gut microbiota, and restoring metabolic homeostasis.

Fufang Taizishen granules (FFTZS) alleviate chemotherapy‐induced intestinal mucositis by enhancing mucosal integrity, reducing inflammation, and modulating gut microbiota composition. In a mouse model, FFTZS improved clinical symptoms, restored tight junction proteins, and corrected amino acid metabolic disturbances. These findings highlight FFTZS as a promising therapeutic strategy for managing mucositis during chemotherapy.