# Phosphate, Fractures, and Frustration—A Missed Diagnosis of Oncogenic Osteomalacia Leading to Multisystem Complication

**Authors:** Ryan Michael Wilson, Lydia Sturridge

PMC · DOI: 10.1002/ccr3.70790 · Clinical Case Reports · 2025-08-11

## TL;DR

This paper discusses a case where a rare condition called oncogenic osteomalacia was missed, leading to serious health issues.

## Contribution

The paper emphasizes the importance of early diagnosis to prevent severe complications.

## Key findings

- Delayed diagnosis of oncogenic osteomalacia can cause multisystem complications.
- Early biochemical assessment and imaging are crucial for accurate diagnosis.
- Multidisciplinary involvement helps avoid misdiagnosis and irreversible health issues.

## Abstract

Persistent hypophosphatemia must prompt thorough evaluation. This case highlights the severe, multisystem consequences of delayed recognition of oncogenic osteomalacia. Early biochemical assessment, imaging, and multidisciplinary involvement are critical to avoid misdiagnosis and prevent irreversible complications such as skeletal fragility and cardiomyopathy.

## Linked entities

- **Diseases:** oncogenic osteomalacia (MONDO:0018124), cardiomyopathy (MONDO:0004994)

## Full-text entities

- **Diseases:** Fractures (MESH:D050723), cardiomyopathy (MESH:D009202), Oncogenic Osteomalacia (MESH:C537751), skeletal fragility (MESH:D005600), hypophosphatemia (MESH:D017674)
- **Chemicals:** Phosphate (MESH:D010710)

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12339412/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12339412/full.md

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Source: https://tomesphere.com/paper/PMC12339412