# Long-term efficacy of deep brain stimulation in PLA2G6-related Parkinson’s disease: A case report with literature review

## TL;DR

A patient with a rare genetic form of Parkinson's disease showed long-term motor improvement with brain stimulation, but also experienced cognitive decline.

## Contribution

Demonstrates long-term motor benefits of DBS in PLA2G6-related Parkinson’s disease and highlights non-motor symptom challenges.

## Key findings

- Deep brain stimulation improved motor function and quality of life for three years in a patient with PLA2G6-related Parkinson’s disease.
- The patient experienced cognitive decline, emphasizing the need to monitor non-motor symptoms in this condition.

## Abstract

A patient with early-onset PARK14 and novel PLA2G6 variants underwent globus pallidus internus deep brain stimulation, achieving sustained three-year motor and quality-of-life improvements. Although a literature review supports motor benefits, our case’s cognitive decline highlights the need for comprehensive assessment of non-motor symptoms and quality-of-life in this rare disorder.