# Advances in the Study of Pluripotent Stem Cells in Livestock

## TL;DR

This paper reviews the potential and challenges of using pluripotent stem cells in livestock for breeding, disease modeling, and organ transplantation.

## Contribution

The paper provides an overview of the classification and regulatory mechanisms of livestock pluripotent stem cells and their future applications.

## Key findings

- Livestock pluripotent stem cells can self-renew and differentiate into various cell types.
- Generating these cells in livestock remains challenging compared to mouse and human models.
- They offer potential for breed improvement, disease modeling, and xenotransplantation.

## Abstract

Livestock pluripotent stem cells, derived either from early embryos or induced through somatic cell reprogramming technology, possess the unique ability to self‐renew, maintain an undifferentiated state and differentiate into various cell types. Consequently, the generation of PSCs from agricultural animal species holds great potential for applications in livestock breed improvement, rapid propagation, disease modelling and xenotransplantation. However, compared to the great achievements made in mouse and human pluripotent stem cells research, the generation of livestock pluripotent stem cells still remains challenging. This article offers an overview of the classification, regulatory mechanisms of pluripotency, and developmental history of livestock pluripotent stem cells, while also anticipating their future application prospects. These insights provide valuable references for the reproduction and breeding of large livestock.

Livestock pluripotent stem cells include embryonic stem cells (ESCs) isolated from the inner cell mass of blastocysts and induced pluripotent stem cells (iPSCs) derived from somatic cell reprogramming. They hold significant potential for applications in livestock breed improvement, rapid propagation, human disease modelling and human organ transplantation.