# RETRACTION: CBX8 Interacts with Chromatin PTEN and Is Involved in Regulating Mitotic Progression

PMC · DOI: 10.1111/cpr.70083 · Cell Proliferation · 2025-06-19

## TL;DR

This retracted paper claimed CBX8 interacts with PTEN to regulate mitosis, but was retracted due to duplicated data from a prior study.

## Contribution

The paper originally proposed a novel interaction between CBX8 and chromatin-bound PTEN in mitotic regulation.

## Key findings

- CBX8 was reported to interact with chromatin-associated PTEN.
- The interaction was suggested to influence mitotic progression.
- Findings were retracted due to duplicated PTEN control data from a prior publication.

## Abstract

RETRACTION: 
ChoiB. H.
, 
ColonT. M.
, 
LeeE.
, 
KouZ.
, 
DaiW.
, “CBX8 Interacts with Chromatin PTEN and Is Involved in Regulating Mitotic Progression,” Cell Proliferation
54, no. 11 (2021): e13110. 10.1111/cpr.13110.34592789
PMC8560621

The above article, published online on 15 December 2020 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Deputy Editor, Yunfeng Lin; and John Wiley & Sons Ltd. A third party reported that the PTEN control bands in Figure 1A had previously been published in another article by some of the same authors (Choi et al. 2017 [https://doi.org/10.1186/s40164‐017‐0079‐0]). Author W. Dai responded to an inquiry by the publisher, but the authors were not able to locate the original data for further analysis. The publisher has confirmed that both articles report on different experimental conditions and time points for both sets of PTEN controls. The retraction has been agreed to because the duplication of the PTEN control data from an earlier publication fundamentally compromises the reliability of the reported results. The authors did not respond to our notice regarding the retraction.

## Linked entities

- **Genes:** CBX8 (chromobox 8) [NCBI Gene 57332], PTEN (phosphatase and tensin homolog) [NCBI Gene 5728]

## Full-text entities

- **Genes:** PTEN (phosphatase and tensin homolog) [NCBI Gene 5728] {aka 10q23del, BZS, CWS1, DEC, GLM2, MHAM}, CBX8 (chromobox 8) [NCBI Gene 57332] {aka PC3, RC1}

## Full text

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Source: https://tomesphere.com/paper/PMC12336447