# A Bibliometric Analysis on Research Trends in Paediatric Epilepsy Treatment From 2005 to 2025

**Authors:** Oliver Squires

PMC · DOI: 10.7759/cureus.87688 · Cureus · 2025-07-10

## TL;DR

This study analyzes global research trends in pediatric epilepsy treatment from 2005 to 2025, showing a shift from traditional drugs to newer therapies like cannabidiol and laser ablation.

## Contribution

The study provides a comprehensive bibliometric analysis highlighting emerging trends and key contributors in pediatric epilepsy treatment research.

## Key findings

- Global publications in pediatric epilepsy treatment increased notably since 2018.
- Research shifted from traditional drug therapies to newer methods like cannabidiol and vagal nerve stimulation.
- The USA and Harvard University were leading in research output and citations.

## Abstract

The objective of this bibliometric analysis was to evaluate trends in paediatric epilepsy treatment research from 2005 to 2025. Through assessing which journals, countries, authors, and institutions have been the most productive and mapping trends in keywords used over time, the study aims to reveal emerging areas of interest and inspire ideas for future research. A total of 1418 relevant documents were retrieved from the Web of Science database. Documents outside of the target time period and non-English documents were excluded. From the 1152 remaining documents, 17 duplicates were removed using OpenRefine (OpenRefine). The final 1135 documents were then analysed using VosViewer (VOSviewer - Visualizing scientific landscapes) and Bibliometrix (https://www.bibliometrix.org/).

The analysis revealed a stable number of annual global publications until a notable increase since 2018. The USA leads the way with the greatest research output (298 articles) and the highest number of total citations (6565). Harvard University emerged as the most productive institution (111 articles), whilst Epilepsia was the most productive journal (253 articles). Keyword co-occurrence analysis revealed a shift in research from earlier documents focusing more on traditional drug therapies to more recent articles focusing on cannabidiol based therapies, laser ablation, and vagal nerve stimulation.

This bibliometric analysis provides new insights into the evolution of paediatric epilepsy treatment research. It helps to demonstrate the leading contributors in the field over the last 20 years, as well as highlighting emerging new trends. The results of the analysis underline the shift in the research away from more traditional treatments to investigating alternative therapies, including cannabidiol based therapies, dietary interventions, laser ablation, and vagal nerve stimulation. Through identifying these trends in the research and mapping author collaboration networks, it is hoped that this study can provide a foundational reference for researchers when planning future studies.

## Linked entities

- **Chemicals:** cannabidiol (PubChem CID 644019)

## Full-text entities

- **Diseases:** Epilepsia (MESH:D017036), Epilepsy (MESH:D004827)
- **Chemicals:** cannabidiol (MESH:D002185)

## Full text

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## Figures

7 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12335356/full.md

## References

27 references — full list in the complete paper: https://tomesphere.com/paper/PMC12335356/full.md

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Source: https://tomesphere.com/paper/PMC12335356