# A Rare Case of Nasopalatine Duct Cyst Diagnosed 7 Years After Secondary Bone Grafting in a Patient With Cleft Lip and Palate

**Authors:** Kazuyuki Yusa, Satoshi Kasuya, Nobuyuki Sasahara, Tomoharu Hemmi, Shigeo Ishikawa

PMC · DOI: 10.1155/crid/5520791 · Case Reports in Dentistry · 2025-08-02

## TL;DR

A rare case of a nasopalatine duct cyst formed after bone grafting in a patient with cleft lip and palate, requiring additional surgery.

## Contribution

Reports a rare complication of cyst formation following secondary bone grafting in cleft patients.

## Key findings

- A nasopalatine duct cyst was diagnosed 5 years after secondary bone grafting in a cleft patient.
- Enucleation and bone grafting resolved the cyst with no recurrence observed postoperatively.
- Damage to the incisive canal during grafting may lead to cyst formation.

## Abstract

Secondary autogenous particulate cancellous bone and marrow grafting (SBG) is a reliable and established technique for patients with alveolar cleft. Some reports have described complications after SBG, but cyst formation in alveolar bone where SBG has been performed appears to be extremely rare. Herein, we report a rare case of a cyst forming at a grafted site 5 years after SBG. A 15-year-old girl was referred to our clinic with a chief complaint of swelling in the right maxilla. The patient had a history of multiple surgeries for cleft lip and palate. Panoramic radiography and computed tomography (CT) revealed a radiolucency in the right maxilla, at the site where SBG had been performed. Enucleation of the lesion and bone graft using particulate cancellous bone and marrow were performed. The histological diagnosis was a nasopalatine duct cyst. Postoperatively, no signs of recurrence have been observed. Some reports have suggested that damage to the incisive canal can lead to the formation of nasopalatine duct cysts. SBG thus needs to be performed with care, as invasion of the incisive canal during the procedure may result in cyst formation and the need for additional surgery.

## Linked entities

- **Diseases:** cleft lip and palate (MONDO:0016044)

## Full-text entities

- **Diseases:** cyst (MESH:D003560), Nasopalatine Duct Cyst (MESH:D015529), alveolar cleft (MESH:D002282), swelling (MESH:D004487), Cleft Lip and Palate (MESH:D002971)
- **Chemicals:** SBG (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC12335353/full.md

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Source: https://tomesphere.com/paper/PMC12335353