# A Case of Primary Cold Agglutinin-Mediated Hemolytic Anemia Successfully Treated with Steroids

## TL;DR

A rare case of cold agglutinin disease was successfully treated with steroids, which is unusual as this condition typically does not respond to such treatment.

## Contribution

Demonstrates successful corticosteroid treatment in a primary cold agglutinin disease case, contrary to typical treatment resistance.

## Key findings

- A 69-year-old male with primary CAD showed marked clinical improvement with prednisone.
- Hemolytic markers normalized following corticosteroid therapy.
- This case suggests corticosteroids may be effective in some primary CAD cases.

## Abstract

Cold agglutinin disease (CAD) is an uncommon subtype of autoimmune hemolytic anemia (AIHA). Cold agglutinin syndrome (CAS) may occur secondary to infections, autoimmune disorders, or malignancies, which must be ruled out to establish a diagnosis of primary CAD. Typically, cold autoimmune hemolytic anemia (cAIHA) is unresponsive to corticosteroid therapy. However, we report a case of a 69-year-old male patient with primary CAD who was successfully treated with corticosteroids. The patient demonstrated marked clinical improvement and normalization of hemolytic markers following treatment with prednisone.