# Familial Frontal Fibrosing Alopecia Occurs Early in Daughters With Affected Mothers: A Case Report and a Review of the Literature

**Authors:** Adrienne Oxenham, Annabel Stevenson

PMC · DOI: 10.1111/ajd.14463 · The Australasian Journal of Dermatology · 2025-04-01

## TL;DR

This paper reports a case of familial frontal fibrosing alopecia in an Australian mother and daughter, highlighting earlier onset in daughters and the need for more research on genetic or environmental factors.

## Contribution

The paper presents the first Australian case of familial FFA and explores clinical differences between familial and sporadic cases.

## Key findings

- Familial FFA occurs earlier in daughters compared to sporadic cases.
- There is a need for further research into genetic or environmental triggers for FFA.
- Eleven familial FFA cases have been reported in the literature.

## Abstract

Frontal fibrosing alopecia (FFA) is a form of cicatricial alopecia that is being increasingly diagnosed in recent years. It predominantly affects post‐menopausal women of various ethnic backgrounds, but cases have also been reported in pre‐menopausal women and rarely in men. Eleven familial cases of FFA have been published in the literature, with some authors raising speculation about potential genetic predisposition or shared exposure to environmental factors as triggers for the condition. Despite this, there remains a lack of detailed characterisation of the clinical features specific to familial cases of FFA. In this report, we aim to contribute to the understanding of FFA by presenting the first Australian case of familial FFA involving a mother and her daughter, while also attempting to define the clinical distinguishing features in familial FFA and sporadic FFA.

## Linked entities

- **Diseases:** frontal fibrosing alopecia (MONDO:0016776)

## Full-text entities

- **Diseases:** cicatricial alopecia (MESH:D000505), FFA (MESH:D005355)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12334806/full.md

## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12334806/full.md

## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC12334806/full.md

---
Source: https://tomesphere.com/paper/PMC12334806