# Claude Syndrome: A Rare but Easily Recognizable Midbrain Lacunar Syndrome

**Authors:** Octavio Carranza, Roxana M Dragomir, Jessica Canosa, Marc A Swerdloff

PMC · DOI: 10.7759/cureus.87505 · Cureus · 2025-07-08

## TL;DR

Claude syndrome is a rare brain condition caused by a stroke in the midbrain, and this paper presents a case study and review of its features.

## Contribution

The paper contributes a detailed case study and comprehensive review of the history and features of Claude syndrome.

## Key findings

- A patient with midbrain infarction showed resolving deficits documented through neuroimaging and video.
- The paper reviews the clinical features and potential causes of Claude syndrome.
- The case highlights the importance of recognizing this rare syndrome for accurate diagnosis.

## Abstract

Claude syndrome (CS) is a rare and classic neurological condition resulting from an isolated midbrain infarction (IMI). Its clinical presentation and anatomical localization remain subjects of ongoing debate in the literature. We present the case of a patient evaluated at our stroke center, with neuroimaging and video documentation of her resolving deficits. In addition, we provide a review of the syndrome’s history, epidemiology, clinical features, and potential etiologies.

## Full-text entities

- **Diseases:** Midbrain Lacunar Syndrome (MESH:D059409), stroke (MESH:D020521), CS (MESH:D020526), neurological condition (MESH:D019636), IMI (MESH:D007238)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12334073/full.md

## References

23 references — full list in the complete paper: https://tomesphere.com/paper/PMC12334073/full.md

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Source: https://tomesphere.com/paper/PMC12334073