# Impact of ventilation and ambient temperature on COVID-19 transmission in clinic waiting rooms: A computational fluid dynamics approach

**Authors:** Zhankun Zhu, Guosheng Gao, Yaoren Hu, Xiansheng Zhao

PMC · DOI: 10.1371/journal.pone.0328154 · PLOS One · 2025-08-08

## TL;DR

This study uses computer modeling to show how ventilation and temperature affect the spread of COVID-19 in clinic waiting rooms, finding that good ventilation can drastically reduce virus levels.

## Contribution

The study introduces detailed modeling of human anatomy and aerosol interactions to improve predictions of virus spread.

## Key findings

- Effective ventilation can reduce virus-laden aerosol concentrations by up to 99.3%.
- Poorly ventilated rooms can have virus concentrations as high as 5.80 kg/m³.
- Modeling human anatomy improves accuracy of viral-trajectory predictions.

## Abstract

The ongoing COVID-19 pandemic underscores the necessity of understanding the transmission dynamics in enclosed, high-risk environments, such as clinic waiting rooms. This study used computational fluid dynamics (CFD) to investigate the behavior of virus-laden aerosols in clinic waiting rooms under six different scenarios with various temperatures and ventilation setups, offering insights into practical strategies for enhancing safety in healthcare environments. Key findings demonstrated that effective ventilation, through open windows and mechanical systems, can reduce virus-laden aerosol concentrations by up to 99.3% under optimal conditions (e.g., from 5.80 kg/m3 to 0.04 kg/m3By contrast, poorly ventilated scenarios exhibit significantly higher viral concentrations, which can rise as high as 5.80 kg/m3. A novel aspect of this research lies in the comprehensive modeling of human anatomy and aerosol interactions, which enhances the accuracy of viral-trajectory predictions. The practical implications include strategic recommendations for ventilation system design to mitigate transmission risks in clinical settings. These insights provide guidelines for healthcare facility design and emphasize the critical role of environmental control in reducing exposure to airborne pathogens.

## Linked entities

- **Diseases:** COVID-19 (MONDO:0100096)

## Full-text entities

- **Diseases:** COVID-19 (MESH:D000086382)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12333980/full.md

## References

50 references — full list in the complete paper: https://tomesphere.com/paper/PMC12333980/full.md

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Source: https://tomesphere.com/paper/PMC12333980