# A Rare Case of Adenocarcinoma of the Urethra

## TL;DR

A rare case of high-grade urethral adenocarcinoma in a 37-year-old man is reported, with treatment choices and outcomes discussed.

## Contribution

This paper presents a rare clinical case of primary urethral adenocarcinoma with detailed diagnostic and treatment considerations.

## Key findings

- The patient was diagnosed with high-grade anterior urethral adenocarcinoma (T1 N0 Mx) after histopathological analysis.
- The patient opted for systemic chemotherapy instead of recommended surgical intervention.
- The case highlights the aggressive nature and diagnostic challenges of primary urethral adenocarcinoma.

## Abstract

Primary urethral adenocarcinoma is a rare and aggressive subtype of primary urethral carcinoma. We report the case of a 37-year-old man with a three-month history of painless hematuria. An initial superficial biopsy revealed poorly differentiated carcinoma with squamous features, but further histopathology after transurethral resection confirmed high-grade anterior urethral adenocarcinoma (T1 N0 Mx) without regional or distant metastasis. After multidisciplinary discussion, urethrectomy with perineal urethrostomy was recommended; however, the patient declined surgery and chose systemic cisplatin-gemcitabine chemotherapy instead.