# Effective Management of Familial Erythrokeratoderma Using Topical Calcipotriol

## TL;DR

This paper reports two cases of a rare skin condition where topical calcipotriol effectively treated symptoms without additional medications.

## Contribution

The novelty lies in demonstrating calcipotriol monotherapy as an effective treatment for familial erythrokeratoderma.

## Key findings

- Topical calcipotriol resolved skin lesions in two PSEK patients.
- Recurrences responded well to calcipotriol without needing corticosteroids or oral drugs.

## Abstract

Progressive symmetrical erythrokeratoderma (PSEK) is a rare genodermatosis that is inherited in an autosomal dominant pattern. It is clinically characterized by the insidious onset of well-defined, non-migratory, erythematous, hyperkeratotic plaques in a symmetrical distribution over the extremities. Hereby, we describe two cases of PSEK in a father and daughter, who presented with bilaterally symmetrical hyperpigmented scaly plaques, with skin biopsy findings suggestive of erythrokeratoderma. The skin lesions resolved with topical calcipotriol monotherapy, without the use of topical corticosteroids or oral medications. During telephonic follow-up, the patients reported that recurrences also responded well to topical calcipotriol, without the need for additional medication. This case report highlights the use of topical calcipotriol as a safe and effective therapeutic alternative for the treatment of erythrokeratoderma.