# Alveolar Lymphangioma in Neonate: A Case Report With Immune Profile

**Authors:** Muhammad Aiman bin Mohd Nizar, Benedict Seo, Haizal M. Hussaini, Brendan Young, Alison M. Rich

PMC · DOI: 10.1111/ipd.13309 · International Journal of Paediatric Dentistry · 2025-03-14

## TL;DR

A rare case of alveolar lymphangioma in a non-Black neonate with an unusual location and appearance is reported, highlighting the importance of biopsy for accurate diagnosis.

## Contribution

This is the first reported case of alveolar lymphangioma in a non-Black neonate with an atypical presentation and location.

## Key findings

- Alveolar lymphangioma was diagnosed in an 11-day-old non-Black neonate with a reddish, lobular mass on the anterior maxillary alveolar ridge.
- Excisional biopsy confirmed the diagnosis and ruled out other potential oral lesions.
- The case emphasizes the need for biopsy in atypical presentations to ensure accurate diagnosis.

## Abstract

Alveolar lymphangioma is a rare condition that commonly develops on the alveolar ridge of Black male neonates. It typically presents as a bluish, dome‐shaped swelling smaller than 1 cm on the posterior alveolar ridge of the mandible or/and maxilla, that allows it to be diagnosed clinically. Most previously reported cases of alveolar lymphangioma report spontaneous resolution, and biopsy is seldom performed unless the lesion becomes symptomatic or interferes with feeding.

We report a case of oral alveolar lymphangioma on the anterior maxillary alveolar ridge of an 11‐day‐old infant of non‐black descent. The lesion presented as a pedunculated, reddish, lobular mass in the anterior maxilla. Given its atypical presentation and the potential for feeding difficulties, an excisional biopsy was performed. The diagnosis was confirmed histologically through biopsy and supported by immunohistochemical staining.

This case expands the understanding of alveolar lymphangioma by reporting it in a non‐Black neonate with an unusual location and appearance, emphasising the need for excisional biopsy to rule out other potential oral lesions, especially neoplasms.

## Linked entities

- **Species:** Homo sapiens (taxon 9606)

## Full-text entities

- **Diseases:** oral lesions (MESH:D009059), Alveolar Lymphangioma (MESH:D008202), neoplasms (MESH:D009369), swelling (MESH:D004487)

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12332113/full.md

## References

5 references — full list in the complete paper: https://tomesphere.com/paper/PMC12332113/full.md

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Source: https://tomesphere.com/paper/PMC12332113