Molecular epidemiology of Nakaseomyces glabrata associated with vulvovaginal candidiasis revealed high genetic variability and the presence of novel genotypes in China
Xue Xu, Yanxia Sun, Danyang Hu, Clement Kin-Ming Tsui, Lu Zhang, Shuwen Deng
TL;DR
This study reveals high genetic diversity and new genotypes of Nakaseomyces glabrata causing vulvovaginal candidiasis in China.
Contribution
The study identifies novel genotypes and sequence types of N. glabrata in China, highlighting genetic variability and potential recombination.
Findings
46 sequence types and 146 genotypes were identified in N. glabrata isolates from China.
ST7 was the most common sequence type, with 69.6% of STs being novel.
Population analysis suggests ST7 may be the founding population of related strains.
Abstract
Nakaseomyces glabrata (former name: Candida glabrata) is the second most common cause of vulvovaginal candidiasis (VVC), but its molecular epidemiology and antifungal resistance in China remain poorly understood. This study analysed 204 N. glabrata isolates from VVC patients in Suzhou, Eastern China, using multi-locus sequence typing (MLST) and microsatellite genotyping, alongside antifungal susceptibility testing. A total of 46 sequence types (STs) were identified by MLST, as well as 146 genotypes (GTs) revealed by microsatellite. According to MLST, ST7 was the predominant ST in vaginal N. glabrata isolates, along with a considerably high proportion (32/46, 69.6%) of novel STs. Notably, 27 STs were unique singletons, of which 25 unique STs were newly defined in this investigation. Microsatellite genotyping revealed a similar pattern as MLST with high variability. Population genetic…
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Taxonomy
TopicsPlant Pathogens and Fungal Diseases · Yeasts and Rust Fungi Studies · Fungal Infections and Studies