# Specialty grand challenge: existing issues and emerging frontiers in renal endocrinology

**Authors:** A. T. M. Emdadul Haque, Mohammed S. Razzaque

PMC · DOI: 10.3389/fendo.2025.1651141 · 2025-07-17

## Full-text entities

- **Genes:** AGT (angiotensinogen) [NCBI Gene 183] {aka ANHU, SERPINA8, hFLT1}, SLC34A3 (solute carrier family 34 member 3) [NCBI Gene 142680] {aka HHRH, NPT2C, NPTIIc}, CYP27B1 (cytochrome P450 family 27 subfamily B member 1) [NCBI Gene 1594] {aka CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR}, NPPA (natriuretic peptide A) [NCBI Gene 4878] {aka ANF, ANP, ATFB6, ATRST2, CDD, CDD-ANF}, PTH (parathyroid hormone) [NCBI Gene 5741] {aka FIH1, PTH1}, CYP11B2 (cytochrome P450 family 11 subfamily B member 2) [NCBI Gene 1585] {aka ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P-450C18}, SLC34A1 (solute carrier family 34 member 1) [NCBI Gene 6569] {aka FRTS2, HCINF2, NAPI-3, NPHLOP1, NPT2, NPTIIa}, VDR (vitamin D receptor) [NCBI Gene 7421] {aka NR1I1, PPP1R163}, EPO (erythropoietin) [NCBI Gene 2056] {aka DBAL, ECYT5, EP, MVCD2}, CALCA (calcitonin related polypeptide alpha) [NCBI Gene 796] {aka CALC1, CGRP, CGRP-I, CGRP-alpha, CGRP1, CT}, PTH1R (parathyroid hormone 1 receptor) [NCBI Gene 5745] {aka EKNS, PFE, PTHR, PTHR1}, FGF23 (fibroblast growth factor 23) [NCBI Gene 8074] {aka ADHR, FGFN, HFTC2, HPDR2, HYPF, PHPTC}, GAST (gastrin) [NCBI Gene 2520] {aka GAS}, REN (renin) [NCBI Gene 5972] {aka ADTKD4, HNFJ2, RTD}, AGTR2 (angiotensin II receptor type 2) [NCBI Gene 186] {aka AT2, ATGR2, MRX88}, NPR1 (natriuretic peptide receptor 1) [NCBI Gene 4881] {aka ANP-A, ANPRA, ANPa, GC-A, GUC2A, GUCY2A}, AVP (arginine vasopressin) [NCBI Gene 551] {aka ADH, ARVP, AVP-NPII, AVRP, VP}, ATP6AP2 (ATPase H+ transporting accessory protein 2) [NCBI Gene 10159] {aka (P)RR, APT6M8-9, ATP6IP2, ATP6M8-9, CDG2R, ELDF10}, OXT (oxytocin/neurophysin I prepropeptide) [NCBI Gene 5020] {aka OT, OT-NPI, OXT-NPI}, KLK4 (kallikrein related peptidase 4) [NCBI Gene 9622] {aka AI2A1, ARM1, EMSP, EMSP1, KLK-L1, PRSS17}
- **Diseases:** toxicity (MESH:D064420), liver cirrhosis (MESH:D008103), Kidney Disease (MESH:D007674), renal anemia (MESH:D000740), cancer (MESH:D009369), water retention (MESH:D016055), diabetic nephropathy (MESH:D003928), hypovolemia (MESH:D020896), osteoporosis (MESH:D010024), resistance to ADH (MESH:D018500), hyponatremia (MESH:D007010), CKD (MESH:D051436), thrombotic (MESH:D013927), Paget's disease of the bone (MESH:D010001), skeletal disorders (MESH:C564967), infarct (MESH:D007238), cardiovascular calcification (MESH:D002318), medullary carcinoma of the thyroid gland (MESH:C536914), primary aldosteronism (OMIM:617027), acute myocardial infarction (MESH:D009203), Diabetes insipidus (MESH:D003919), secondary hyperparathyroidism (MESH:D006962), stroke (MESH:D020521), hypotension (MESH:D007022), mineral and bone disorders (MESH:D012080), heart failure (MESH:D006333), endothelial dysfunction (MESH:D014652), reperfusion injuries (MESH:D015427), SIADH (MESH:D007177), hypertension (MESH:D006973), phosphate dysregulation (MESH:D021081), hyperphosphatemia (MESH:D054559), inflammatory (MESH:D007249), fracture (MESH:D050723), ascites (MESH:D001201), hypocalcemia (MESH:D006996)
- **Chemicals:** water (MESH:D014867), oxygen (MESH:D010100), Calcitriol (MESH:D002117), prostaglandins (MESH:D011453), Phosphate (MESH:D010710), denosumab (MESH:D000069448), V2 receptor antagonists (-), calcium (MESH:D002118), HS (MESH:D006497), potassium (MESH:D011188), sodium (MESH:D012964), corticosterone (MESH:D003345), 25-hydroxyvitamin D (MESH:C104450), 1,25-dihydroxyvitamin D (MESH:C097949), bisphosphonates (MESH:D004164), cortisol (MESH:D006854), paricalcitol (MESH:C084656), Aldosterone (MESH:D000450), Vitamin D (MESH:D014807)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12329770/full.md

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Source: https://tomesphere.com/paper/PMC12329770