# Developing foundations for biomedical knowledgebases from literature using large language models – A systematic assessment

## TL;DR

This paper evaluates how well large language models can extract biomedical knowledge from scientific literature to build knowledgebases.

## Contribution

The study introduces a benchmark for comparing LLMs in 11 biomedical knowledge extraction tasks.

## Key findings

- LLM performance varies significantly based on task difficulty and technical specialization.
- Providing source text with answers helps address some challenges in knowledge extraction.
- Prompting LLMs to include source text is difficult to standardize effectively.

## Abstract

While large language models (LLMs) have shown promising capabilities in biomedical applications, measuring their reliability in knowledge extraction remains a challenge. We developed a benchmark to compare LLMs in 11 literature knowledge extraction tasks that are foundational to automatic knowledgebase development, with or without task-specific examples supplied. We found large variation across the LLMs’ performance, depending on the level of technical specialization, difficulty of tasks, scattering of original information, and format and terminology standardization requirements. We also found that asking the LLMs to provide the source text behind their answers is useful for overcoming some key challenges, but that specifying this requirement in the prompt is difficult.