Saltations of cis-regulatory modules in Canidae and Hominidae
Jianhui Shi, Linting Wang, Lei M. Li
TL;DR
The study explores how changes in gene regulation may explain the unique social abilities of dogs compared to wolves and humans.
Contribution
The paper introduces a novel method using CREF matrices and eigen-modules to detect regulatory saltations in canids and hominids.
Findings
The fourth and fifth eigen-modules show regulatory saltations specific to dogs.
Enhanced myelination, memory, and cochlear development are linked to these saltations in dogs and humans.
Dogs and humans share a more similar cognition-memory module than humans and chimpanzees.
Abstract
Dogs, which were segregated from wolves about thirty thousand years ago, show unique human-similar social-cognitive abilities. However, the genomic basis accounting for the phenotypic saltation between dog and wolf remains unclear. We performed a comparative analysis of genome-wide cis-regulatory element frequencies (CREF) for five canids: dog, dingo, red fox, dhole, and wolf, along with four hominids. For each species, genome-wide CREFs are organized into a matrix. The species-specific CREF matrix is stratified into multiple dual eigen-modules through robust singular value decomposition. Cross-species comparisons of dual eigen-modules demonstrated that the top three eigen-modules are highly conserved while the fourth and fifth ones underwent a saltation in dogs. The red fox is closest to the degenerate point characterizing the onset of saltation. Gene enrichment analysis and motif…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsHuman-Animal Interaction Studies · Marine animal studies overview · Infant Health and Development