# Effect of catheter ablation with vein of Marshall ethanol infusion for perimitral flutter in a patient with senile transthyretin cardiac amyloidosis: a case report

## TL;DR

A 75-year-old man with heart disease and a rare amyloid condition had successful treatment using a specialized catheter ablation technique.

## Contribution

Demonstrates successful catheter ablation with vein of Marshall ethanol infusion in a patient with senile transthyretin cardiac amyloidosis.

## Key findings

- The patient showed significant improvement in heart failure symptoms and ejection fraction after the procedure.
- No arrhythmia recurrence was observed during a 48-month follow-up.
- Ethanol infusion in the vein of Marshall was critical for successful ablation in this complex case.

## Abstract

Senile transthyretin cardiac amyloidosis (AL) is an underdiagnosed infiltrative cardiomyopathy causing heart failure symptoms in elderly patients. It is associated with a higher incidence of atrial fibrillation (AF) and atrial flutter.

A 75-year-old male patient with senile transthyretin cardiac AL presented with congestive heart failure [New York Heart Association (NYHA) IV] related to rapid perimitral atrial flutter, causing tachycardia-induced cardiomyopathy with a left ventricular ejection fraction (LVEF) of 25%. He underwent AF voltage-guided ablation with vein of Marshall (VOM) ethanol infusion to block the mitral isthmus. Left atrial bipolar voltage mapping revealed diffuse and severe left atrial low-voltage areas related to amyloid protein infiltration within the left atrium (LA). After a 48-month follow-up, no arrhythmia recurrence was observed. Heart failure symptoms improved significantly (NYHA I–II) with an improved LVEF of approximately 45%–50%.

Diffuse and severe left atrial fibrosis related to amyloid protein infiltration within the LA is generally associated with worse catheter ablation outcomes in cardiac AL patients. This case demonstrated that the VOM ethanol infusion was critical to the success of the catheter ablation procedure, resulting in a better long-term outcome.