# Anxiety and perceived social support as moderators of cognitive and emotional well-being in populations affected by COVID-19

**Authors:** Jonathan Zegarra-Valdivia, Brenda Chino-Vilca, Leandro Pérez-Fernández, Milagros Casimiro-Arana, Harold Arana-Nombera, Viviana Nayelli Gallegos-Manayay, María del Rosario Oliva-Piscoya, Reyna Alamo-Medina, Eduardo Abanto-Saldaña, Nobuko Vásquez-Zuñe, Lisseth Detquizan Pérez, Diana Gutierrez-Flores, Leslie Lozada Tantarico, Naydelin Hernández, María Celinda Cruz-Ordinola, Carmen Paredes-Manrique

PMC · DOI: 10.3389/fpubh.2025.1562894 · Frontiers in Public Health · 2025-07-24

## TL;DR

This study examines how anxiety and social support affect cognitive and emotional well-being in people who had COVID-19.

## Contribution

The study identifies anxiety and perceived social support as key moderators of cognitive performance in post-COVID-19 populations.

## Key findings

- Individuals with a history of COVID-19 had lower cognitive scores compared to controls.
- Anxiety strengthens the link between social cognition and perceived support.
- Perceived social support reduces the negative impact of age on cognition.

## Abstract

The COVID-19 pandemic has raised significant concerns about its long-term impact on cognitive and emotional functioning. This study explores the role of anxiety and social variables in shaping cognitive performance among individuals with a history of COVID-19 infection.

This retrospective cross-sectional study included 227 Peruvian adults, classified into control, acute phase, and hyperinflammatory phase groups based on COVID-19 symptomatology. Cognitive performance was assessed using the Addenbrooke’s Cognitive Examination (ACE), focusing on global cognition. Anxiety levels, social cognition, and perceived social support were also measured. Moderation analyses were conducted to explore whether anxiety moderated the relationship between social cognition and perceived support, and whether support moderated the relationship between age and cognition.

Individuals with a history of COVID-19, particularly those in the acute and hyperinflammatory phases, showed significantly lower ACE scores than controls. Anxiety moderated the relationship between social cognition and perceived social support, with stronger associations at higher anxiety levels. Additionally, perceived support moderated the effect of age on cognitive performance, especially in individuals with low to moderate support.

These findings highlight the complex interplay between psychological and social factors in cognitive functioning following COVID-19. Understanding these relationships is crucial for developing integrated interventions that address cognitive and psychosocial recovery in affected populations.

## Linked entities

- **Diseases:** COVID-19 (MONDO:0100096)

## Full-text entities

- **Diseases:** Anxiety (MESH:D001007), COVID-19 (MESH:D000086382)

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12328151/full.md

## References

73 references — full list in the complete paper: https://tomesphere.com/paper/PMC12328151/full.md

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Source: https://tomesphere.com/paper/PMC12328151