# Secondary Renal Injury and Encephalopathy Syndrome Caused by Systemic Lupus Erythematosus With Overlapping Sjögren's Syndrome in Children: A Case Report

## TL;DR

This case report describes a child with a rare overlap of two autoimmune diseases, SLE and Sjögren's syndrome, leading to kidney and brain complications.

## Contribution

The paper presents a rare case of SLE overlapping with Sjögren's syndrome in a child, highlighting its complex clinical manifestations.

## Key findings

- The case involved secondary acute renal injury and encephalopathy due to SLE with overlapping Sjögren's syndrome.
- Early diagnosis and treatment are crucial for improving prognosis in such complex autoimmune cases.
- There is a lack of published reports on this overlap, especially in pediatric populations.

## Abstract

Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) are chronic, multisystem disorders. When the two coexist, the manifestations become more complex and diverse, and early diagnosis and treatment are a key to improving the patient prognosis. However, to date, only scarce reports have been published, especially overlap syndrome. We review the diagnosis and treatment process of a case of acute renal injury and encephalopathy syndrome secondary to SLE with overlapping SS to gain a comprehensive understanding of the disease with review of the current literature.