# Mesenchymal Stromal/Stem Cells in the Tumor Microenvironment and Their Role in Tumor Progression: Mesenchymal Stromal/Stem Cells and Tumor Progression

## TL;DR

This paper reviews how mesenchymal stromal/stem cells interact with tumors and whether they help or hinder tumor growth.

## Contribution

The study provides a comprehensive review of the dual role of MSCs in tumor progression.

## Key findings

- MSCs can influence tumor progression by interacting within the tumor microenvironment.
- The role of MSCs in tumor development remains controversial, with evidence suggesting both promotion and inhibition.
- MSCs are considered promising therapeutic candidates but their exact impact on tumors is still unclear.

## Abstract

Mesenchymal stromal/stem cells (MSCs) are a source of stem cells that can be
easily harvested and differentiated into numerous cells. Over the past few
decades, these cells have been introduced as promising therapeutic candidates
for different diseases. Different studies have shown the role of these cells in
regenerative medicine. Tumor growth is correlated with the interactions between
MSCs and tumor cells in the tumor microenvironment. The precise key role played
by MSCs in the progression of tumors is under question, and the effect of MSCs
on the tumor is controversial it might involve the development of tumor
initiation or prevent the spread of already existing ones. In this study, we
reviewed the role of MSCs in the tumor microenvironment and their influence on
promoting or inhibiting tumor progression.