# Digestive System Involvement During Coronavirus Disease 2019; the Newest Clinical Features and Potential Mechanisms: Digestive System Involvements and COVID-19

## TL;DR

This paper reviews how the digestive system is affected in patients with COVID-19 and explores possible mechanisms behind these effects.

## Contribution

The paper provides a comprehensive summary of clinical features and mechanisms of digestive system involvement in COVID-19.

## Key findings

- Gastrointestinal symptoms are common in a significant proportion of COVID-19 patients.
- Liver and pancreatic involvement are also observed in some patients with the disease.
- The mechanisms behind these digestive system involvements remain unclear and require further study.

## Abstract

The coronavirus disease 2019 (COVID-19), which is caused by the severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), has been recognized as a
worldwide pandemic and mostly affects the respiratory system. A considerable
proportion of patients; however, might also experience gastrointestinal (GI)
manifestations. Several investigations have assessed GI and hepatic involvement
in this disease, although the mechanisms of these involvements in relation to
the progression of COVID-19 remain unclear. This review summarized the clinical
observations and the main mechanisms behind GI, liver, and pancreatic
involvement among COVID-19 patients.