# Concurrent Metastatic Clear Cell Renal Cell Carcinoma and Chronic Lymphocytic Leukemia Within the Same Lymph Node: A Case Report and Review of Dual Malignancy Management

## TL;DR

A rare case of a man with both kidney cancer and leukemia is reported, highlighting the challenges of managing two cancers at once.

## Contribution

This case report adds to the limited literature on concurrent clear cell renal cell carcinoma and chronic lymphocytic leukemia.

## Key findings

- A patient with chronic lymphocytic leukemia developed metastatic clear cell renal cell carcinoma.
- Concurrent malignancies were confirmed through biopsy of a lymph node.
- The case emphasizes the need for tailored management strategies for dual cancers.

## Abstract

Dual malignancies involving clear cell renal cell carcinoma (ccRCC) and chronic lymphocytic leukemia (CLL) present a rare and challenging clinical scenario. This report describes a 75-year-old male with a history of monoclonal B-cell lymphocytosis (MBL) that progressed to CLL, later complicated by the development of ccRCC. Following neoadjuvant pembrolizumab, he underwent left nephrectomy with pathology confirming renal cell carcinoma (RCC). Subsequent imaging revealed a recurrent renal bed nodule, and a retroperitoneal lymph node biopsy demonstrated concurrent CLL and metastatic RCC. Our report aims to enhance recognition and management strategies for such complex dual malignancies.