# A unified annotation scheme for class D β-lactamases

## TL;DR

This paper introduces a standardized system for describing the structure of class D β-lactamase enzymes to improve research and communication in the field.

## Contribution

The paper proposes a unified annotation scheme for secondary structure features of class D β-lactamases.

## Key findings

- The scheme will help compare biochemical and biophysical studies across different enzymes in this class.
- It aims to improve clarity and consistency in scientific communication about these enzymes.

## Abstract

A standardized scheme for numbering and annotation of secondary structure features has been proposed for class D β-lactamases (F. Attana, S. Kim, J. Spencer, B. I. Iorga, et al., Antimicrob Agents Chemother 69:e00150-25, 2025, https://doi.org/10.1128/aac.00150-25). This will significantly facilitate the comparison of biochemical and biophysical studies performed on the disparate members of this class of enzymes and improve communication in the field.