# Salivary and serum leptin levels in oral lichen planus patients. A case-control study

## TL;DR

This study found that leptin levels in saliva and blood are higher in people with oral lichen planus compared to healthy individuals, suggesting leptin may play a role in the disease.

## Contribution

The study is the first to compare salivary and serum leptin levels in oral lichen planus patients and healthy controls.

## Key findings

- Salivary and serum leptin levels are significantly higher in OLP patients.
- Higher leptin levels suggest a possible involvement in the pathogenesis of OLP.
- Age differences between groups did not affect the study results.

## Abstract

Lichen planus (LP) is a chronic inflammatory disease. Oral lichen planus (OLP) is a chronic inflammatory disease that affects the oral mucosa. Different clinical types of oral lichen planus can be diagnosed based on clinical presentation and histopathological features.

The present study aimed to assess the potential of salivary and serum leptin in the diagnosis of OLP.

The study was conducted on 78 cases (i.e., 39 cases per group) with OLP. The subjects were systematically free. Salivary and serum leptin concentrations from patients exhibiting a classic OLP and from healthy controls were assessed.

Salivary and serum leptin levels are higher in the OLP group. The participants in the study are older than those in the control group; therefore, the age difference between the two groups does not affect the study’s results.

Salivary and serum leptin levels in OLP patients were higher than in healthy control subjects, suggesting a possible role in the process of OLP pathogenesis.