# Anti-neuroinflammatory therapy for non-pulsatile tinnitus in patients with sinus vascular anomalies: preliminary result on two cases

## TL;DR

This study suggests that anti-inflammatory treatment may help reduce non-pulsatile tinnitus in patients with sinus vascular issues.

## Contribution

The study presents preliminary evidence that anti-neuroinflammatory therapy can alleviate non-pulsatile tinnitus linked to sinus vascular anomalies.

## Key findings

- Two patients with non-pulsatile tinnitus and sinus stenosis showed reduced tinnitus after anti-inflammatory treatment.
- Imaging revealed structural vascular abnormalities that may contribute to neuroinflammation and tinnitus.
- The results suggest a potential therapeutic role for anti-inflammatory agents in this condition.

## Abstract

Vascular anomalies are commonly associated with pulsatile tinnitus, but their potential role in triggering non-pulsatile tinnitus through neuroinflammation is not well established. Furthermore, few studies have investigated non-pulsatile tinnitus associated with altered cerebrovascular supply and whether anti-neuroinflammatory therapy might alleviate symptoms.

We describe two patients presenting with non-pulsatile tinnitus and sigmoid sinus stenosis confirmed by imaging, with other causes systematically excluded.

Magnetic resonance venography demonstrated severe stenosis of the transverse and sigmoid sinuses, alongside compensatory ipsilateral vascular dilatation. These structural abnormalities suggested disrupted venous blood flow, contributing to the neuroinflammatory processes associated with non-pulsatile tinnitus. Following treatment with an anti-inflammatory molecule, both patients reported a substantial reduction in tinnitus severity.

This study supports the potential of anti-inflammatory treatments in managing non-pulsatile tinnitus linked to sinus vascular anomalies. Further research is warranted to elucidate these relationships and confirm therapeutic efficacy of anti-inflammatory agents.