# Case Report: Liquid-based cytology diagnosis of pulmonary mucormycosis

## TL;DR

A case report describes the diagnosis of a rare and dangerous fungal lung infection using non-invasive cytology techniques.

## Contribution

This case highlights the effectiveness of liquid-based cytology and cell block preparation in diagnosing pulmonary mucormycosis.

## Key findings

- Pulmonary mucormycosis was diagnosed using conventional cytological smear, liquid-based cytology, and cell block preparation.
- Liquid-based cytology and cell block techniques provided a non-invasive and faster diagnostic approach.
- The patient had a history of diabetes, a known risk factor for mucormycosis.

## Abstract

Mucormycosis is an infrequent yet life-threatening opportunistic fungal infection, typically secondary to diabetic ketoacidosis. Owing to its non-specific clinical presentation and auxiliary test findings, timely diagnosis remains difficult. While fungal culture, direct smear, histopathological biopsy, and molecular diagnostic techniques are available, cytological evaluation and histopathological biopsy remain the principal modalities in clinical settings. Notably, cytological identification of mucorales remains rare.

A 41-year-old male presented with a 20-day history of productive cough and fever, accompanied by a recent onset of hemoptysis. His medical history included type 2 diabetes mellitus. Diagnostic confirmation of mucormycosis was achieved through conventional cytological smear, liquid-based cytology, cell block preparation, tissue biopsy, and specialized staining techniques. Pulmonary mucormycosis was ultimately diagnosed.

This report documents a case of pulmonary mucormycosis identified via conventional cytological smear, liquid-based cytology, and cell block preparation. Liquid-based cytology and cell block techniques offered a non-invasive and more expedient approach, highlighting their value in the early identification and intervention of mucormycosis.