# Case Report: First report of a Wilms tumor in an individual with Dias–Logan syndrome (BCL11A-related intellectual disability)

## TL;DR

This case report describes the first instance of a Wilms tumor in a child with Dias–Logan syndrome, a rare genetic condition.

## Contribution

The novelty lies in identifying the first cancer case in a DLS patient, raising questions about a potential link.

## Key findings

- A child with Dias–Logan syndrome was diagnosed with Wilms tumor, an event not previously reported.
- The tumor occurred at an older age than typical Wilms tumor onset.
- The report suggests a possible but unproven association between DLS and cancer predisposition.

## Abstract

Dias–Logan syndrome (DLS) is a rare condition caused by heterozygous germline BCL11A pathogenic variants associated with global developmental delay, distinctive facial features, and asymptomatic persistence of fetal hemoglobin. There has been no evidence of an association between DLS and increased risk of cancer. We report the first instance of a child with DLS diagnosed with cancer, a Wilms tumor (WT), who is notably much older than the typical onset. Although this case alone is insufficient to warrant routine WT screening in DLS, given the extreme rarity, we cannot rule out an association with DLS and WT predisposition.