# Classic Hodgkin's Lymphoma With Epstein–Barr Viremia and Lymphadenopathy

**Authors:** Zulma D. Sosa Carcamo, Salvador Alvarez, Joan M. Irizarry Alvarado

PMC · DOI: 10.1155/carm/4599207 · Case Reports in Medicine · 2025-07-29

## TL;DR

This paper presents a case of classic Hodgkin's Lymphoma linked to Epstein–Barr virus viremia, occurring 15 years after infectious mononucleosis.

## Contribution

The novelty lies in the long latency period between EBV infection and HL development in this specific case.

## Key findings

- The patient developed EBV-associated classic HL 15 years after infectious mononucleosis.
- The case highlights the potential long-term oncogenic risk of EBV infection.

## Abstract

Hodgkin's lymphoma (HL) is uncommon, and its etiology has been attributed to infectious sources such as Epstein–Barr virus (EBV). Though pathogenesis is not completely understood, studies have revealed that specific viral proteins from EBV conduct the process of HL development. In this report, we will discuss the case of a patient who developed EBV-associated classic HL 15 years after an episode of infectious mononucleosis.

## Linked entities

- **Diseases:** Hodgkin's lymphoma (MONDO:0004952), infectious mononucleosis (MONDO:0005810)

## Full-text entities

- **Genes:** BCL6 (BCL6 transcription repressor) [NCBI Gene 604] {aka BCL5, BCL6A, LAZ3, ZBTB27, ZNF51}, CD8A (CD8 subunit alpha) [NCBI Gene 925] {aka CD8, CD8alpha, IMD116, Leu2, p32}, CD19 (CD19 molecule) [NCBI Gene 930] {aka B4, CVID3}, FUT4 (fucosyltransferase 4) [NCBI Gene 2526] {aka CD15, ELFT, FCT3A, FUC-TIV, FUTIV, LeX}, PWWP3A (PWWP domain containing 3A, DNA repair factor) [NCBI Gene 84939] {aka EXPAND1, HSPC211, MUM-1, MUM1}, CD4 (CD4 molecule) [NCBI Gene 920] {aka CD4mut, IMD79, Leu-3, OKT4D, T4}, PAX5 (paired box 5) [NCBI Gene 5079] {aka ALL3, BSAP, PAX-5}, KRT20 (keratin 20) [NCBI Gene 54474] {aka CD20, CK-20, CK20, K20, KRT21}, TNFRSF8 (TNF receptor superfamily member 8) [NCBI Gene 943] {aka CD30, D1S166E, Ki-1}, S100A1 (S100 calcium binding protein A1) [NCBI Gene 6271] {aka S100, S100-alpha, S100A}, PTPRC (protein tyrosine phosphatase receptor type C) [NCBI Gene 5788] {aka B220, CD45, CD45R, GP180, IMD105, L-CA}, CD5 (CD5 molecule) [NCBI Gene 921] {aka LEU1, T1}, CD79A (CD79a molecule) [NCBI Gene 973] {aka IGA, IGAlpha, MB-1, MB1}, MLANA (melan-A) [NCBI Gene 2315] {aka MART-1, MART1}
- **Diseases:** lymphoproliferative diseases (MESH:D008232), hepatomegaly (MESH:D006529), lymphocytosis (MESH:D008218), EBV infection (MESH:D020031), Lymphadenopathy (MESH:D008206), pharyngitis (MESH:D010612), gastric carcinoma (MESH:D013274), IM (MESH:D007244), Classic Hodgkin's Lymphoma (MESH:D006689), tuberculosis (MESH:D014376), HIV (MESH:D015658), tonsillitis (MESH:D014069), anemia (MESH:D000740), nasopharyngeal carcinoma (MESH:D000077274), non-Hodgkin's lymphoma (MESH:D008228), rash (MESH:D005076), weight loss (MESH:D015431), respiratory infection (MESH:D012141), Burkitt's lymphoma (MESH:D002051), pruritus (MESH:D011537), Epstein-Barr Viremia (MESH:D014766), infectious disease (MESH:D003141), cancer (MESH:D009369), infected (MESH:D007239), chills (MESH:D023341), splenomegaly (MESH:D013163), neck mass (MESH:D006258), fever (MESH:D005334)
- **Chemicals:** ABVD (-), nivolumab (MESH:D000077594), dacarbazine (MESH:D003606)
- **Species:** Homo sapiens (human, species) [taxon 9606], Felis catus (cat, species) [taxon 9685], human gammaherpesvirus 4 (Epstein Barr virus, no rank) [taxon 10376]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12324906/full.md

## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12324906/full.md

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Source: https://tomesphere.com/paper/PMC12324906