# Endoscopic Cholecystoduodenostomy With Lumen-Apposing Metal Stent for Bile Duct Stricture in a Child with Neuroblastoma: A Case Report

**Authors:** Maria Stella Cipriani, Liliana Piro, Federico Palo, Andrea Chiaro, Stefania Sorrentino, Paolo Gandullia, Andrea Parodi, Stefano Avanzini

PMC · DOI: 10.1055/a-2662-2339 · European Journal of Pediatric Surgery Reports · 2025-08-05

## TL;DR

A 6-year-old child with neuroblastoma developed a bile duct stricture after surgery, which was successfully treated with a new endoscopic procedure using a metal stent.

## Contribution

This case report introduces endoscopic cholecystoduodenostomy with a lumen-apposing metal stent as a novel approach for pediatric postoperative bile duct strictures.

## Key findings

- Endoscopic cholecystoduodenostomy successfully managed an anastomotic stricture in a child with neuroblastoma.
- The procedure was performed using a lumen-apposing metal stent between the gallbladder and duodenum.
- The approach shows potential for treating iatrogenic bile duct strictures in pediatric patients.

## Abstract

We report the use of endoscopic cholecystoduodenostomy in a 6-year-old child to manage postanastomotic stricture of the common bile duct (CBD) secondary to an intraoperative injury sustained during the resection of an abdominal neuroblastoma (NB). The patient was diagnosed with stage M NB, characterized by dissemination to the bone marrow and vertebrae, and MYCN amplification. Following multiple cycles of chemotherapy and subsequent hematopoietic stem cell transplantation, the patient was scheduled for surgical resection. Preoperative imaging identified several image-defined risk factors, including infiltration of the porta hepatis and of the duodenopancreatic complex. During the dissection of the tumor, an incidental injury to the CBD occurred, which was subsequently repaired via end-to-end anastomosis. Seven months postoperatively, the patient presented with obstructive jaundice due to an anastomotic stricture, which was successfully managed through the placement of an endoscopic ultrasound-guided lumen-apposing metal stent (LAMS) between the dilated gallbladder and the duodenum. In our experience, endoscopic cholecystoduodenostomy constitutes a novel approach for addressing postoperative iatrogenic CBD strictures in pediatric patients. Further research is warranted to elucidate its benefits and risks as well as to evaluate its long-term efficacy and potential for broader application.

## Linked entities

- **Diseases:** neuroblastoma (MONDO:0005072), obstructive jaundice (MONDO:0006874)

## Full-text entities

- **Genes:** MYCN (MYCN proto-oncogene, bHLH transcription factor) [NCBI Gene 4613] {aka FGLDS1, MODED, MPAPA, MYCNsORF, MYCNsPEP, N-myc}
- **Diseases:** acute cholecystitis (MESH:D041881), cholelithiasis (MESH:D002769), dilation (MESH:D002311), liver failure (MESH:D017093), Tumor (MESH:D009369), abdominal tumors (MESH:D000008), stage M (MESH:C566367), visceral injury (MESH:D007418), biliary obstruction (MESH:D001658), necrosis (MESH:D009336), biliary complications (MESH:D008107), OJ (MESH:D041781), jaundice (MESH:D007565), bleeding (MESH:D006470), CBD injury (MESH:D003137), bile duct dilation (MESH:D001649), injury (MESH:D014947), M abdominal NB (MESH:D009447), Stricture (MESH:D003251), biliary tract stricture (MESH:D001660)
- **Chemicals:** bilirubin (MESH:D001663), catecholamines (MESH:D002395), LAMS (-)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC12324853/full.md

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Source: https://tomesphere.com/paper/PMC12324853